Background: Treat-to-target therapy is effective for patients with rheumatoid arthritis (RA),
but long-term results of continued targeted treatment are lacking. Objective: To evaluate long-…

Introduction Flares in patients with rheumatoid arthritis are suggested to sometimes
spontaneously resolve. Targeted therapy could then entail possible overtreatment. We aimed to …

Objective. To evaluate the prevalence of anti–extractable nuclear antigen (anti-ENA)
antibodies in Dutch SSc patients and the predictive power of the combination of specific anti-ENA …

Objective. To determine whether a multibiomarker disease activity (MBDA) score predicts
radiographic damage progression in the subsequent year in patients with early rheumatoid …

Objective Rheumatoid arthritis (RA) is a chronic disease leading to joint destruction.
Although many studies have addressed factors potentially correlated with the speed of joint …

To compare rheumatologists’ adherence to treatment protocols for rheumatoid arthritis (RA)
targeted at Disease Activity Score (DAS) ≤2.4 or <1.6. The BeSt-study enrolled 508 early …

Objective To determine the most effective treatment strategy among anticitrullinated protein
antibodies (ACPA)-negative patients with early rheumatoid arthritis. Methods In the BeSt …

Objectives To compare outcomes of targeted treatment aimed at either low disease activity
or remission in patients with early active rheumatoid arthritis (RA). Methods Five-year …

Objective. To assess linear extrapolation (LE) and last observation carried forward (LOCF)
as imputation methods for radiographic change in patients with RA. Methods. The OSKIRA-1 …

… correspondence to Iris M. Markusse, MD, Leiden University Medical Center, Department
of Rheumatology, PO Box 9600, 2300 RC Leiden, The Netherlands. E-mail: immarkusse@lumc.…