Background Thymectomy has been a mainstay in the treatment of myasthenia gravis, but
there is no conclusive evidence of its benefit. We conducted a multicenter, randomized trial …

Multiple Sclerosis (MS) annualized relapse rates (ARRs) in trials may be declining due to
changes in diagnostic criteria, MS etiology, study criteria, and selection biases. This review …

Background— Studies of the effect of right ventricular ejection fraction (RVEF) on outcomes
in heart failure (HF) are limited by small sample size and short follow-up. Methods and …

Time-to-event outcomes are common in medical research as they offer more information than
simply whether or not an event occurred. To handle these outcomes, as well as censored …

Background Tissue Doppler index E/è is used clinically and in multidisciplinary research for
estimation of left ventricular filling pressure ( LVFP ) and diastolic dysfunction ( DD )/heart …

Aims To determine the effects of digoxin on all-cause mortality and heart failure (HF)
hospitalizations, regardless of ejection fraction, accounting for serum digoxin concentration (SDC). …

Observational studies indicate a significant relation between dietary sodium and level of blood
pressure. However, the role of salt sensitivity in the development of resistant hypertension …

Background The treatment of symptomatic congenital cytomegalovirus (CMV) disease with
intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at 6 …

The Pareto distribution is a simple model for nonnegative data with a power law probability
tail. In many practical applications, there is a natural upper bound that truncates the …

Chronic kidney disease (CKD) is common and is associated with increased mortality in heart
failure (HF). However, it is unknown whether the effect of CKD on mortality varies by left …