OBJECTIVE: Our objective was to develop a framework to identify research gaps from
systematic reviews. STUDY DESIGN AND SETTING: We reviewed the practices of (1) evidence-…

Background While identifying and cataloging unpublished studies from conference
proceedings is generally recognized as a good practice during systematic reviews, controversy …

Environmental risk factors that have an impact on the ocular surface were reviewed and
associations with age and sex, race/ethnicity, geographical area, seasonality, prevalence and …

Context: Determining which patients with thyroid nodules require surgery is limited by
cytologically indeterminate findings. A new approach for preoperative molecular classification of …

Objectives To review evidence about the uptake of core outcome sets (COS). A COS is an
agreed standardized set of outcomes that should be measured and reported, as a minimum, in …

Importance Dry eye is a common clinical manifestation, a leading cause of eye clinic visits,
and a significant societal and personal economic burden in the United States. Meibomian …

Purpose: Sjögren's syndrome (SS) is a common autoimmune disease affecting about four
million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous …

Purpose Among adult individuals with dry eye, assess the self-reported impact of the COVID-19
pandemic on (1) dry eye-related visual function, (2) reading efficiency, and (3) dry eye …

Introduction Choice of outcomes is critical for clinical trialists and systematic reviewers. It is
currently unclear how systematic reviewers choose and pre-specify outcomes for systematic …

Background People with cystic fibrosis experience chronic airway infections as a result of
mucus build up within the lungs. Repeated infections often cause lung damage and disease. …