The immunogenic part of infliximab is the F (ab′) 2, but measuring antibodies to the intact infliximab molecule is more clinically useful
…, O Picard, E Fudim, D Coscas, S Bar-Meir, I Goldstein… - Gut, 2011 - gut.bmj.com
Objectives To localise the immunogenic part of infliximab and evaluate the clinical usefulness
of measuring antibodies against infliximab fragments. Design Observational study. …
of measuring antibodies against infliximab fragments. Design Observational study. …
Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots
…, SW Feigelson, T Meshel, SM Nurmi, I Goldstein… - Nature …, 2012 - nature.com
Chemokines presented by the endothelium are critical for integrin-dependent adhesion and
transendothelial migration of naive and memory lymphocytes. Here we found that effector …
transendothelial migration of naive and memory lymphocytes. Here we found that effector …
TNF activates a NF-κB–regulated cellular program in human CD45RA–regulatory T cells that modulates their suppressive function
…, I Bank, Y Kloog, G Rechavi, I Goldstein - The Journal of …, 2010 - journals.aai.org
Emerging data suggest that regulatory T cell (Treg) dysfunction and consequent breakdown
of immunological self-tolerance in autoimmunity can be mediated by factors that are not Treg…
of immunological self-tolerance in autoimmunity can be mediated by factors that are not Treg…
Cell contact-dependent acquisition of cellular and viral nonautonomously encoded small RNAs
…, L Flomenblit, FV Karginov, I Goldstein… - Genes & …, 2009 - genesdev.cshlp.org
In some organisms, small RNA pathways can act nonautonomously, with responses
spreading from cell to cell. Dedicated intercellular RNA delivery pathways have not yet been …
spreading from cell to cell. Dedicated intercellular RNA delivery pathways have not yet been …
Fine tuning and efficient T cell activation with stimulatory aCD3 nanoarrays
J Matic, J Deeg, A Scheffold, I Goldstein, JP Spatz - Nano letters, 2013 - ACS Publications
Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with
site-directed protein immobilization techniques represent a novel T cell stimulatory platform …
site-directed protein immobilization techniques represent a novel T cell stimulatory platform …
MDR1 expression identifies human melanoma stem cells
GI Keshet, I Goldstein, O Itzhaki, K Cesarkas… - Biochemical and …, 2008 - Elsevier
ABC transporters are often found to be inherently expressed in a wide variety of stem cells,
where they provide improved protection from toxins. We found a subpopulation of human …
where they provide improved protection from toxins. We found a subpopulation of human …
[HTML][HTML] Intercellular exchange of proteins: the immune cell habit of sharing
O Rechavi, I Goldstein, Y Kloog - FEBS letters, 2009 - Elsevier
The recent recognition of new types of cell–cell communication pathways challenges classic
theories of cell autonomy. Evidence of functional “proteome mixing” among interacting cells, …
theories of cell autonomy. Evidence of functional “proteome mixing” among interacting cells, …
[HTML][HTML] RNA editing by ADAR1 leads to context-dependent transcriptome-wide changes in RNA secondary structure
…, EY Levanon, N Amariglio, R Unger, I Goldstein… - Nature …, 2017 - nature.com
Adenosine deaminase acting on RNA 1 (ADAR1) is the master RNA editor, catalyzing the
deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of …
deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of …
Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population
…, Y Mor, E Fridman, I Goldstein… - Journal of cellular …, 2009 - Wiley Online Library
During development, renal stem cells reside in the nephrogenic blastema. Wilms’ tumour (WT),
a common childhood malignancy, is suggested to arise from the nephrogenic blastema …
a common childhood malignancy, is suggested to arise from the nephrogenic blastema …
Epigenetic inheritance of DNA methylation limits activation-induced expression of FOXP3 in conventional human CD25−CD4+ T cells
…, G Rechavi, N Amariglio, I Goldstein - International …, 2008 - academic.oup.com
The transcription factor forkhead box P3 (FOXP3 in humans; Foxp3 in mice) controls the
development and function of regulatory T cells (Treg). In mice, CD4 + CD25 − T cells do not …
development and function of regulatory T cells (Treg). In mice, CD4 + CD25 − T cells do not …