Objectives To localise the immunogenic part of infliximab and evaluate the clinical usefulness
of measuring antibodies against infliximab fragments. Design Observational study. …

Chemokines presented by the endothelium are critical for integrin-dependent adhesion and
transendothelial migration of naive and memory lymphocytes. Here we found that effector …

Emerging data suggest that regulatory T cell (Treg) dysfunction and consequent breakdown
of immunological self-tolerance in autoimmunity can be mediated by factors that are not Treg…

In some organisms, small RNA pathways can act nonautonomously, with responses
spreading from cell to cell. Dedicated intercellular RNA delivery pathways have not yet been …

Anti-CD3 (aCD3) nanoarrays fabricated by self-assembled nanopatterning combined with
site-directed protein immobilization techniques represent a novel T cell stimulatory platform …

ABC transporters are often found to be inherently expressed in a wide variety of stem cells,
where they provide improved protection from toxins. We found a subpopulation of human …

The recent recognition of new types of cell–cell communication pathways challenges classic
theories of cell autonomy. Evidence of functional “proteome mixing” among interacting cells, …

Adenosine deaminase acting on RNA 1 (ADAR1) is the master RNA editor, catalyzing the
deamination of adenosine to inosine. RNA editing is vital for preventing abnormal activation of …

During development, renal stem cells reside in the nephrogenic blastema. Wilms’ tumour (WT),
a common childhood malignancy, is suggested to arise from the nephrogenic blastema …

The transcription factor forkhead box P3 (FOXP3 in humans; Foxp3 in mice) controls the
development and function of regulatory T cells (Treg). In mice, CD4 + CD25 − T cells do not …