The two tandem bromodomains of the BET (bromodomain and extraterminal domain) proteins
enable chromatin binding to facilitate transcription. Drugs that inhibit both bromodomains …

Effective antiviral immunity depends on the ability of infected cells or cells triggered with
virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of …

Objective To determine whether the plasma levels of a range of inflammatory proteins have
utility as biomarkers of disease activity in rheumatoid arthritis (RA) patients. Methods Plasma …

Memory T cells possess functional differences from naïve T cells that powerfully contribute
to the efficiency of secondary immune responses. These abilities are imprinted during the …

The properties of a cell are determined both genetically by the DNA sequence of its genes
and epigenetically through processes that regulate the pattern, timing and magnitude of …

Pan-bromodomain and extra terminal (BET) inhibitors interact equipotently with all eight
bromodomains of the BET family of proteins. They have shown profound efficacy in vitro and in …

Herein we describe the design and synthesis of a dual active histone deacetylase (HDAC)/bromodomain
and extra terminal (BET) small molecule tool inhibitor, DUAL946 (1). Exploiting …

10.7554/eLife.04631.001 Epigenetic modifiers are an emerging class of anti-tumor drugs,
potent in multiple cancer contexts. Their effect on spontaneously developing autoimmune …

Innate immune responses rely on inducible gene expression programmes which, in contrast
to steady-state transcription, are highly dependent on cohesin. Here we address …

Latency reversal strategies for HIV cure using inhibitor of apoptosis protein (IAP) antagonists
(IAPi) induce unprecedented levels of latent reservoir expression without immunotoxicity …