Interleukin‐6 and soluble interleukin‐6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast‐like cell formation
…, N Takahashi, N Udagawa, I Nakamura… - Journal of Bone and …, 2020 - academic.oup.com
Chronic immune responses and inflammatory reactions in rheumatoid arthritis (RA) often
cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy…
cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy…
Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
Bone destruction is a pathological hallmark of several chronic inflammatory diseases, including
rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort results …
rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort results …
Regulation of osteoclast function
T Suda, I Nakamura, E Jimi… - Journal of bone and …, 1997 - academic.oup.com
OSTEOCLASTIC BONE RESORPTION consists of several compli-cated processes: osteoclast
development, attachment of osteoclasts to calcified tissues, development of a ruffled …
development, attachment of osteoclasts to calcified tissues, development of a ruffled …
Interleukin 1 induces multinucleation and bone-resorbing activity of osteoclasts in the absence of osteoblasts/stromal cells
E Jimi, I Nakamura, LT Duong, T Ikebe… - Experimental cell …, 1999 - Elsevier
Interleukin-1 (IL-1) is one of the most potent bone-resorbing factors involved in bone loss
associated with inflammation. We previously reported that IL-1 prolonged the survival of …
associated with inflammation. We previously reported that IL-1 prolonged the survival of …
Integrins and signaling in osteoclast function
LT Duong, P Lakkakorpi, I Nakamura, GA Rodan - Matrix Biology, 2000 - Elsevier
Integrins are heterodimeric adhesion receptors that mediate cell–matrix and cell–cell
interactions. Osteoclasts highly express the αvβ3 integrin, which binds to a variety of extracellular …
interactions. Osteoclasts highly express the αvβ3 integrin, which binds to a variety of extracellular …
PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha (v) beta3 integrin, and phosphorylated by src kinase.
LT Duong, PT Lakkakorpi, I Nakamura… - The Journal of …, 1998 - Am Soc Clin Investig
Osteoclast activation is initiated by adhesion to the bone surface, followed by cytoskeletal
rearrangement, the formation of the sealing zone, and a polarized ruffled membrane. This …
rearrangement, the formation of the sealing zone, and a polarized ruffled membrane. This …
Role of αvβ3 integrin in osteoclast migration and formation of the sealing zone
I Nakamura, MF Pilkington… - Journal of cell …, 1999 - journals.biologists.com
The α v β 3 integrin is abundantly expressed in osteoclasts and has been implicated in the
regulation of osteoclast function, especially in cell attachment. However, in vivo studies have …
regulation of osteoclast function, especially in cell attachment. However, in vivo studies have …
Involvement of αvβ3 integrins in osteoclast function
I Nakamura, LT Duong, SB Rodan… - Journal of bone and …, 2007 - Springer
Integrins are heterodimeric adhesion receptors that mediate cell–matrix interaction. Osteoclast
exhibits high expression of the α v β 3 integrin, which binds to a variety of extracellular …
exhibits high expression of the α v β 3 integrin, which binds to a variety of extracellular …
Osteoclast function is activated by osteoblastic cells through a mechanism involving cell-to-cell contact
E Jimi, I Nakamura, H Amano, Y Taguchi… - …, 1996 - academic.oup.com
We have established a method for obtaining an enriched preparation of functionally active
osteoclast-like multinucleated cells (enriched OCLs) from co-cultures of mouse primary …
osteoclast-like multinucleated cells (enriched OCLs) from co-cultures of mouse primary …
The small gtp-binding protein, RHO p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts
D Zhang, N Udagawa, I Nakamura… - Journal of cell …, 1995 - journals.biologists.com
Rho protein (rho p21), a p21 ras -related small guanine nucleotide binding protein, regulates
cytoskeletal organization in a number of different types of cells. Evidence has indicated that …
cytoskeletal organization in a number of different types of cells. Evidence has indicated that …