Chronic immune responses and inflammatory reactions in rheumatoid arthritis (RA) often
cause severe destruction of cartilage and bone, but its mechanism is still a matter of controversy…

Bone destruction is a pathological hallmark of several chronic inflammatory diseases, including
rheumatoid arthritis and periodontitis. Inflammation-induced bone loss of this sort results …

OSTEOCLASTIC BONE RESORPTION consists of several compli-cated processes: osteoclast
development, attachment of osteoclasts to calcified tissues, development of a ruffled …

Interleukin-1 (IL-1) is one of the most potent bone-resorbing factors involved in bone loss
associated with inflammation. We previously reported that IL-1 prolonged the survival of …

Integrins are heterodimeric adhesion receptors that mediate cell–matrix and cell–cell
interactions. Osteoclasts highly express the αvβ3 integrin, which binds to a variety of extracellular …

Osteoclast activation is initiated by adhesion to the bone surface, followed by cytoskeletal
rearrangement, the formation of the sealing zone, and a polarized ruffled membrane. This …

The α v β 3 integrin is abundantly expressed in osteoclasts and has been implicated in the
regulation of osteoclast function, especially in cell attachment. However, in vivo studies have …

Integrins are heterodimeric adhesion receptors that mediate cell–matrix interaction. Osteoclast
exhibits high expression of the α v β 3 integrin, which binds to a variety of extracellular …

We have established a method for obtaining an enriched preparation of functionally active
osteoclast-like multinucleated cells (enriched OCLs) from co-cultures of mouse primary …

Rho protein (rho p21), a p21 ras -related small guanine nucleotide binding protein, regulates
cytoskeletal organization in a number of different types of cells. Evidence has indicated that …