There is a growing realization that some aging-associated phenotypes/diseases have an
epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during …

Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is ∼50%,
implicating roles for genetic and non-genetic factors in the aetiology of this complex …

OBJECTIVE Specific autoantibodies characterize type 1 diabetes in childhood but are also
found in adult-onset diabetes, even when initially non–insulin requiring, eg, with latent …

There is increasing evidence that interindividual epigenetic variation is an etiological factor
in common human diseases. Such epigenetic variation could be genetic or non-genetic in …

OBJECTIVE—HbA 1c (A1C) is substantially determined by genetic factors not shared in
common with glucose. Fractions of the variance in A1C, the glycation gap (GG; previously called …

The incidence of type 1 diabetes (T1D) has substantially increased over the past decade,
suggesting a role for non-genetic factors such as epigenetic mechanisms in disease …

OBJECTIVE: To measure levels of IgG antibodies against structurally related synthetic peptides
of HLA-DRB1*0404, type XI collagen, and Proteus mirabilis in patients with rheumatoid …

In type 1 diabetes, diabetes-associated autoantibodies, including islet cell antibodies (ICAs),
reflect adaptive immunity, while increased serum N ε -carboxymethyl-lysine (CML), an …

A major concern in common disease epigenomics is distinguishing causal from consequential
epigenetic variation. One means of addressing this issue is to identify the temporal origins …

OBJECTIVE—There is evidence that monocytes of patients with type 1 diabetes show
proinflammatory activation and disturbed migration/adhesion, but the evidence is inconsistent. Our …