Objective To develop and validate new classification criteria for adult and juvenile idiopathic
inflammatory myopathies (IIM) and their major subgroups. Methods Candidate variables …

In this study, we have identified the source of nitric oxide (NO) produced in the human
inflammatory joints by analyzing expression of inducible NO synthase. In ex vivo organ cultures, …

Objective To describe the methodology used to develop new classification criteria for adult
and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods …

Introduction Increased activity of osteoclasts is responsible for bone loss and joint
destruction in rheumatoid arthritis. For osteoclast development and bone resorption activity, …

B7 homologous protein (B7h)/B7-related protein 1 (B7RP-1) is a new member of the B7
family of costimulatory molecules that specifically interacts with inducible costimulator (ICOS) …

Objectives To investigate the duration of remission and low disease activity (LDA) after cessation
of tocilizumab (TCZ) treatment in rheumatoid arthritis patients who showed remission or …

Synovial tissue affected by rheumatoid arthritis is characterized by proliferation, which leads
to irreversible cartilage and bone destruction. Current and experimental treatments have …

Idiopathic inflammatory myopathies (IIMs) are heterogeneous disorders that affect the skeletal
muscles. Polymyositis, dermatomyositis, and inclusion body myositis are major IIM subsets…

Objective Autoantibodies to aminoacyl-tRNA synthetases (ARSs) are useful in the diagnosis
of idiopathic inflammatory myopathy (IIM) with interstitial pneumonia (IP). We developed an …

The IL-6-triggered positive feedback loop for NFκB signaling (or the IL-6 amplifier/Inflammation
amplifier) was originally discovered as a synergistic-activation signal that follows IL-17/IL-…