… As discussed here b15 Helgi Valdimarsson and colleagues, cytokines scleased by the
superanti& (SAg)-stimulated T cells could induce or enhance the expression of the crossreactive …

Psoriasis is a T-cell-mediated chronic inflammatory skin disease believed to be of autoimmune
nature that can be triggered or worsened by streptococcal throat infections. In addition to …

Psoriasis is strongly associated with streptococcal throat infection, and patients have
increased occurrence of such infections. Psoriatic lesional T cells are oligoclonal, and T cells …

Psoriasis is associated with HLA-Cw6, and Caucasians who carry this allele have about a
10-fold increased risk of developing psoriasis. We have HLA-C typed 369 patients with …

Low-dose methotrexate (MTX) is an established and highly effective treatment for severe
psoriasis and rheumatoid arthritis; however, its mechanism of action remains unclear. We …

A major susceptibility gene for psoriasis is located in the major histocompatibility complex
class I region on chromosome 6 very close to the HLA-Cw6 gene. We collected a cohort of …

Double staining immunofluorescent techniques and monoclonal antibodies were used to
study the numbers, distribution, HLA‐DR expression and relationship of T‐cell subpopulations …

Background. Previous studies have shown associations between low mannose-binding lectin
(MBL) level or variant MBL2 genotype and sepsis susceptibility. However, MBL deficiency …

Several genetic loci have been reported for psoriasis, but none has been specifically linked
to psoriatic arthritis (PsA), a condition that affects >10% of patients with psoriasis. A genetic …

Narrow-band ultraviolet B (UVB) phototherapy is an effective treatment for psoriasis. Owing
to its limited penetration, the direct effects of UVB are mostly restricted to cells residing in the …