Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting ∼1%
of the adult population worldwide, with an estimated heritability of 60%. To identify genes …

Background The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA, USA) can detect tuberculosis
and its multidrug-resistant form with very high sensitivity and specificity in controlled studies, …

The tundra is warming more rapidly than any other biome on Earth, and the potential ramifications
are far-reaching because of global feedback effects between vegetation and climate. …

Rapid progress has been made in the development of new diagnostic assays for tuberculosis
in recent years. New technologies have been developed and assessed, and are now …

Notch is a transmembrane receptor that controls cell fate decisions in Drosophila and whose
role in mammalian cell fate decisions is beginning to be explored. We are investigating the …

Intensifying wildfire activity and climate change can drive rapid forest compositional shifts. In
boreal North America, black spruce shapes forest flammability and depends on fire for …

In boreal forests, climate warming is shifting the wildfire disturbance regime to more
frequent fires that burn more deeply into organic soils, releasing sequestered carbon to the …

As the permafrost region warms, its large organic carbon pool will be increasingly vulnerable
to decomposition, combustion, and hydrologic export. Models predict that some portion of …

The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601)
in the hematopoietic-specific protein tyrosine phosphatase gene, PTPN22, has been …

Through litter decomposition enormous amounts of carbon is emitted to the atmosphere.
Numerous large-scale decomposition experiments have been conducted focusing on this …