Increased CD40 expression on articular chondrocytes from patients with rheumatoid arthritis: contribution to production of cytokines and matrix metalloproteinases.
H Gotoh, Y Kawaguchi, M Harigai, M Hara… - The Journal of …, 2004 - jrheum.org
OBJECTIVE: To examine expression of CD40 on articular chondrocytes derived from patients
with rheumatoid arthritis (RA) and osteoarthritis (OA) and to investigate roles of CD40 on …
with rheumatoid arthritis (RA) and osteoarthritis (OA) and to investigate roles of CD40 on …
The polycomb component Ring1B regulates the timed termination of subcerebral projection neuron production during mouse neocortical development
…, J Shinga, M Vidal, H Koseki, Y Gotoh - …, 2014 - journals.biologists.com
In the developing neocortex, neural precursor cells (NPCs) sequentially generate various
neuronal subtypes in a defined order. Although the precise timing of the NPC fate switches is …
neuronal subtypes in a defined order. Although the precise timing of the NPC fate switches is …
[PDF][PDF] Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition
…, T Toyoda, J Shinga, H Koseki, M Vidal, Y Gotoh - Neuron, 2009 - cell.com
During neocortical development, neural precursor cells (NPCs, or neural stem cells) produce
neurons first and astrocytes later. Although the timing of the fate switch from neurogenic to …
neurons first and astrocytes later. Although the timing of the fate switch from neurogenic to …
A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development
…, Y Hirabayashi, H Koseki, Y Gotoh - Proceedings of the …, 2012 - National Acad Sciences
The proneural basic helix–loop–helix (bHLH) transcription factor neurogenin1 (Neurog1)
plays a pivotal role in neuronal differentiation during mammalian development. The …
plays a pivotal role in neuronal differentiation during mammalian development. The …
Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review
…, Y Morita, K Nishiwaki, H Ninomiya, A Gotoh… - International Journal of …, 2016 - Springer
Pregnancy with paroxysmal nocturnal hemoglobinuria (PNH) is associated with significant
risk of complications, such as life-threatening thrombosis. Recently, eculizumab has come …
risk of complications, such as life-threatening thrombosis. Recently, eculizumab has come …
[PDF][PDF] Ubiquitination-independent repression of PRC1 targets during neuronal fate restriction in the developing mouse neocortex
…, W Yokozeki, H Koseki, Y Hirabayashi, Y Gotoh - Developmental cell, 2018 - cell.com
Polycomb repressive complex (PRC) 1 maintains developmental genes in a poised state
through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 …
through monoubiquitination (Ub) of histone H2A. Although Ub-independent functions of PRC1 …
Adhesion and shrinkage transform the rounded pupal horn into an angular adult horn in Japanese rhinoceros beetle
Clarifying the mechanisms underlying shape alterations during insect metamorphosis is
important for understanding exoskeletal morphogenesis. The large horn of the Japanese …
important for understanding exoskeletal morphogenesis. The large horn of the Japanese …
[HTML][HTML] The Polycomb group protein Ring1 regulates dorsoventral patterning of the mouse telencephalon
…, H Sugishita, S Utsunomiya, H Koseki, Y Gotoh - Nature …, 2020 - nature.com
Dorsal-ventral patterning of the mammalian telencephalon is fundamental to the formation
of distinct functional regions including the neocortex and ganglionic eminence. While Bone …
of distinct functional regions including the neocortex and ganglionic eminence. While Bone …
Secondary structure characterization based on amino acid composition and availability in proteins
JM Otaki, M Tsutsumi, T Gotoh… - Journal of chemical …, 2010 - ACS Publications
The importance of thorough analyses of the secondary structures in proteins as basic structural
units cannot be overemphasized. Although recent computational methods have achieved …
units cannot be overemphasized. Although recent computational methods have achieved …
[HTML][HTML] Genetical control of 2D pattern and depth of the primordial furrow that prefigures 3D shape of the rhinoceros beetle horn
The head horn of the Asian rhinoceros beetle develops as an extensively folded primordium
before unfurling into its final 3D shape at the pupal molt. The information of the final 3D …
before unfurling into its final 3D shape at the pupal molt. The information of the final 3D …