Background Previous studies have shown that alendronate can increase bone mineral
density (BMD) and prevent radiographically defined (morphometric) vertebral fractures. The …

ContextRaloxifene hydrochloride, a selective estrogen receptor modulator, prevents bone
loss in postmenopausal women, but whether it reduces fracture risk in these women is not …

Background Once-daily injections of parathyroid hormone or its amino-terminal fragments
increase bone formation and bone mass without causing hypercalcemia, but their effects on …

The assessment of vertebral fracture by conventional radiography has been refined and
improved using either semiquantitative or quantitative criteria. The inter‐ and intraobserver …

ContextRisedronate, a potent bisphosphonate, has been shown to be effective in the treatment
of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it …

Background Osteoporotic structural damage and bone fragility result from reduced bone
formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an orally …

Bisphosphonates (BPs) and denosumab reduce the risk of spine and nonspine fractures.
Atypical femur fractures (AFFs) located in the subtrochanteric region and diaphysis of the femur …

Background: The treatment of open fractures of the tibial shaft is often complicated by delayed
union and nonunion. The objective of this study was to evaluate the safety and efficacy of …

Background Osteoporotic fractures, including clinically detected vertebral fractures, are
associated with increased mortality. However, only one third of vertebral fractures are diagnosed. …

Reports linking long‐term use of bisphosphonates (BPs) with atypical fractures of the femur
led the leadership of the American Society for Bone and Mineral Research (ASBMR) to …