The human major histocompatibility complex (MHC) region has been shown to be associated
with numerous diseases. However, it remains a challenge to pinpoint the causal variants …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

Autoimmune diseases are a group of heterogeneous disorders characterized by damage to
various organs caused by abnormal innate and adaptive immune responses. The …

Cell-free DNA (cfDNA) released from damaged or dead cells can activate DNA sensors that
exacerbate the pathogenesis of rheumatoid arthritis (RA). Here we show that ~40 nm …

Purpose This study was designed to compare the effectiveness of systemic methotrexate (MTX)
with uterine artery embolization (UAE) combined with local MTX for the treatment of …

Fibroblast-like synoviocytes (FLSs) are critical to synovial aggression and joint destruction
in rheumatoid arthritis (RA). The role of long noncoding RNAs (lncRNAs) in RA is largely …

Introduction Adipose derived mesenchymal stem cells (ADMSCs), carrying the similar
characteristics to bone marrow mesenchymal stem cells, only much more abundant and easier to …

Objective There is increasing evidence that the RhoA signaling pathway may play a critical
role in the inflammatory response. This study was undertaken to examine the effects of RhoA …

Background and Purpose Abnormal glycolytic metabolism contributes to joint inflammation
in rheumatoid arthritis (RA). The aims of this study were to investigate the role of 6‐…

Objective. To explore the roles of the bromodomain (Brd) and extra-terminal domain (BET)
of chromatin adaptors in regulating synovial inflammation in RA. Methods. Fibroblast-like …