This is a two-volume series research monograph on the general Lagrangian Floer theory
and on the accompanying homological algebra of filtered $ A_\infty $-algebras. This book …

The generation of properly functioning gametes in vitro requires reconstitution of the multistepped
pathway of germ cell development. We demonstrate here the generation of primordial …

We introduced the notion of weakly unobstructed Lagrangian submanifolds and constructed
their potential function ( PO ) purely in terms of A -model data in [FOOO3]. In this article, we …

Reconstitution of female germ cell development in vitro is a key challenge in reproductive
biology and medicine. We show here that female (XX) embryonic stem cells and induced …

The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed
to be associated with epigenetic errors including abnormal DNA hypermethylation. Recently, …

Specification of the germ cell lineage is vital to development and heredity. In mice, the germ
cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying …

Mechanisms underlying human germ cell development are unclear, partly due to difficulties
in studying human embryos and lack of suitable experimental systems. Here, we show that …

Stem cell regulatory mechanisms are difficult to study because self-renewal and production
of differentiated progeny, which are both strictly controlled, occur simultaneously in these …

Vertical integration of successive monopolists (with fixed production coefficients) has long
been known to provide merging monopolists with greater profit and their customers with …

In serum, mouse embryonic stem cells (mESCs) fluctuate between a naive inner cell mass (ICM)-like
state and a primed epiblast-like state, but when cultured with inhibitors of the …