We identified a p53 target gene, phosphate-activated mitochondrial glutaminase (GLS2), a
key enzyme in conversion of glutamine to glutamate, and thereby a regulator of glutathione (…

The incidence of thyroid carcinoma has been increasing worldwide. This is interpreted as an
increase in the incidental detection of papillary thyroid microcarcinomas (PTMCs). However…

The tumor suppressor p53 regulates multiple cellular functions, including energy metabolism.
Metabolic deregulation is implicated in the pathogenesis of some cancers and in …

The liver stores glycogen and releases glucose into the blood upon increased energy
demand. Group 2 innate lymphoid cells (ILC2) in adipose and pancreatic tissues are known for …

BACKGROUND: Primary aldosteronism caused by aldosterone-producing adenoma is the
most common curable cause of secondary hypertension, but despite resection, many patients …

The clinical characteristics of growth hormone (GH)-producing pituitary adenomas/somatotroph
pituitary neuroendocrine tumors (GHomas/somatotroph PitNETs) vary across patients. In …

Context: Pheochromocytoma is a catecholamine-producing tumor that originates from adrenal
chromaffin cells and is capable of secreting various hormones, including ACTH. Case …

The rapid progression of chronic kidney disease and higher incidence of cardiovascular
complications are well known in patients with hyperaldosteronism. However, detailed renal …

Fructose-1,6-bisphosphatase (FBPase) deficiency, caused by an FBP1 mutation, is an
autosomal recessive disorder characterized by hypoglycemic lactic acidosis. Due to the rarity of …

Objective Correct interpretation of renal function in patients with primary aldosteronism is
difficult before adrenalectomy, because subtle kidney impairment is often masked by …