[HTML][HTML] Activation mechanisms of monocytes/macrophages in adult-onset Still disease

…, H Toko, F Honda, A Kitada, H Miki… - Frontiers in …, 2022 - frontiersin.org
Adult onset Still disease (AOSD) is a systemic inflammatory disorder characterized by skin
rash, spiking fever, arthritis, sore throat, lymphadenopathy, and hepatosplenomegaly. …

TWEAK functions with TNF and IL-17 on keratinocytes and is a potential target for psoriasis therapy

RK Gupta, DT Gracias, DS Figueroa, H Miki… - Science …, 2021 - science.org
TNF and IL-17 are two cytokines that drive dysregulated keratinocyte activity, and their
targeting is highly efficacious in patients with psoriasis, but whether these molecules act with …

Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces

…, Y Nakamura, Y Nakazawa, N Totsuka, H Miki… - Nature …, 2016 - nature.com
Epithelial tissues continually undergo apoptosis. Commensal organisms that inhabit the
epithelium influence tissue homeostasis, in which regulatory T cells (T reg cells) have a central …

Microneedle-mediated intratumoral delivery of anti-CTLA-4 promotes cDC1-dependent eradication of oral squamous cell carcinoma with limited irAEs

…, F Soto, DJ Ramms, M Proietto, Z Mikulski, H Miki… - Molecular cancer …, 2022 - AACR
Head and neck squamous cell carcinoma (HNSCC) ranks sixth in cancer incidence
worldwide and has a 5-year survival rate of only 63%. Immunotherapies—principally immune …

Novel fibroblast phenotypes in homeostasis and chronic inflammation: From functions to potential regulators

H Miki, MC Manresa - The Journal of Physiology, 2023 - Wiley Online Library
Fibroblasts are essential components of the stroma, sustaining a variety of tissues and being
key to the process of tissue repair after injury. Their role in tissue repair has been attributed …

A deficiency in the cytokine TNFSF14/LIGHT limits inflammation and remodeling in murine eosinophilic esophagitis

MC Manresa, H Miki, J Miller, K Okamoto… - The Journal of …, 2022 - journals.aai.org
Eosinophilic esophagitis (EoE) is a chronic type 2 allergic disease, with esophageal tissue
remodeling as the mechanism behind clinical dysphagia and strictures. IL-13 is thought to be …

Effectiveness of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis. An open label, multicenter, one-year, prospective study: ROSE …

…, A Ohyama, F Honda, H Asashima, H Miki… - Modern …, 2016 - academic.oup.com
Objective: To clarify the efficacy and safety of abatacept for secondary Sjögren’s syndrome (SS)
associated with rheumatoid arthritis (RA). Methods: The primary endpoint of this open-…

A case of refractory Kimura disease with a buccal bulky mass successfully treated with low-dose cyclosporine A: report and review of the literature

H Miki, H Tsuboi, S Kaneko, H Takahashi… - Allergology …, 2016 - jstage.jst.go.jp
Kimura disease (KD) is a chronic inflammatory disorder that presents as painless
lymphadenopathy or subcutaneous masses, most predominantly in the head and neck region. …

Involvement of CD300a phosphatidylserine immunoreceptor in aluminum salt adjuvant–induced Th2 responses

H Miki, C Nakahashi-Oda, T Sumida… - The Journal of …, 2015 - journals.aai.org
Aluminum salt (alum) has been widely used for vaccinations as an adjuvant. Alum not only
enhances immunogenicity but also induces Th2 cell immune responses. However, the …

Efficacy and safety of abatacept for patients with Sjögren's syndrome associated with rheumatoid arthritis: rheumatoid arthritis with orencia trial toward Sjögren's …

…, C Hagiya, H Asashima, C Takai, H Miki… - Modern …, 2015 - academic.oup.com
Objective. To assess the efficacy and safety of abatacept for secondary Sjögren's syndrome (SS)
associated with rheumatoid arthritis (RA). Methods. The primary endpoint of this 1-year, …