1. The blood–brain barrier is essential for the maintenance and regulation of the neural
microenvironment. The main characteristic features of blood–brain barrier endothelial cells are …

The blood–brain barrier is essential for the maintainance and regulation of the neural
microenvironment. The blood–brain barrier endothelial cells comprise an extremely low rate of …

The microenvironment of the CNS is important for neuronal function, and the blood-brain
barrier is involved in its maintenance. The barrier is present in a complex cellular system at the …

TIE-1 and Tie-2 define a new class of receptor tyrosine kinases that are specifically expressed
in developing vascular endothelial cells. To study the functions of Tie-1 and Tie-2 during …

The association of pericytes (PCs) to newly formed blood vessels has been suggested to
regulate endothelial cell (EC) proliferation, survival, migration, differentiation, and vascular …

Vascular endothelial growth factor (VEGF) is an important regulator of vasculogenesis,
angiogenesis, and vascular permeability. In contrast to its transient expression during the …

We have generated a novel transgenic mouse model on a C57BL/6J genetic background
that coexpresses KM670/671NL mutated amyloid precursor protein and L166P mutated …

The blood–brain barrier (BBB) is confined to the endothelium of brain capillaries and is
indispensable for fluid homeostasis and neuronal function. In this study, we show that endothelial …

Recently targeted disruption of Omi/HtrA2 has been found to cause neurodegeneration and
a parkinsonian phenotype in mice. Using a candidate gene approach, we performed a …

The intracerebral injection of β-amyloid–containing brain extracts can induce cerebral β-amyloidosis
and associated pathologies in susceptible hosts. We found that intraperitoneal …