Oxygen metabolism has an important role in the pathogenesis of rheumatoid arthritis. Reactive
oxygen species (ROS) produced in the course of cellular oxidative phosphorylation, and …

Immune-mediated inflammatory diseases (IMID) present a group of common and highly
disabling chronic conditions that share inflammatory pathways. Several incidence and …

Established and emerging data demonstrate that a 'preclinical' period of disease precedes
the onset of clinical rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as …

Effector T cell responses can be modulated by competing positive or negative signals
transduced by natural killer (NK) cell receptors. This raises the possibility that dominant T cell …

Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in
the inflamed synovium. To address the mechanism, we analyzed chemokine receptor …

Statement of findings An inception cohort of 238 patients having peripheral joint synovitis of
less than 12 months duration was evaluated clinically and followed prospectively for 1 year …

Rheumatoid arthritis (RA) is accompanied by synovial inflammation, proliferation, and
cartilage destruction. The reasons the activation of synovial fibroblasts often persists despite …

Objective Stromal cell–derived factor 1 (SDF‐1; or, CXCL12) is a potent chemotactic and
angiogenic factor that has been proposed to play a role in the recruitment of lymphocytes into …

Background Immune-mediated inflammatory disease (IMID) represents a substantial health
concern. It is widely recognized that IMID patients are at a higher risk for developing …

Objective. Anticitrullinated protein antibodies (ACPA) are relatively specific for rheumatoid
arthritis (RA), and predate disease. The oral pathogen Porphyromonas gingivalis may play a …