Background/Aim: We examined the influence of chronic treatment with angiotensin-(1–7) [Ang-(1–7)]
on renox (renal NADPH oxidase, NOX-4) and the development of renal dysfunction …

Although diabetes is a major risk factor for vascular diseases, eg, hypertension and
atherosclerosis, mechanisms that underlie the “risky” aspects of diabetes remain obscure. The …

Although exogenous administration of Angiotensin-(1–7) [Ang-(1–7)] can prevent development
of diabetes induced end-organ damage, little is known about the role of endogenous Ang…

Background Type 1 diabetes mellitus (T1DM) is highly prevalent in Kuwait with incidence of
around 40.1/100,000 individuals. Evidence indicate that vitamin D plays an important role in …

In this study, by using highly purified rat liver peroxisomes, we provide evidence from analytical
cell fractionation, Western blot, and immunocytochemical analysis that Cu-Zn superoxide …

BACKGROUND AND PURPOSE The transactivation of the epidermal growth factor (EGF)
receptor appears to be an important central transduction mechanism in mediating diabetes‐…

Earlier, we reported that rat liver peroxisomes contain Cu-Zn superoxide dismutase (J. Biol.
Chem. 267, 6870), thereby suggesting a new antioxidant role for this organelle in free radical …

The mechanisms by which angiotensin-(1–7) [Ang-(1–7)] exerts its beneficial effects on end-organ
damage associated with diabetes and hypertension are not well understood. The …

Background The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the
highest in the world. Vitamin D is considered to be involved in immune modulation and its …

Transactivation of the epidermal growth factor receptor (EGFR or ErbB) family members,
namely EGFR and ErbB2, appears important in the development of diabetes-induced vascular …