Focal cerebral ischemia elicits a strong inflammatory response involving early recruitment of
granulocytes and delayed infiltration of ischemic areas and the boundary zones by T cells …

Background and Purpose— The simplistic view of atherosclerosis as a disorder of
pathological lipid deposition has been redefined by the more complex concept of an ongoing …

Axotomy or crush of a peripheral nerve leads to degeneration of the distal nerve stump
referred to as Wallerian degeneration (WD). During WD a microen‐vironment is created that …

This review article on the degeneration and regeneration of peripheral nerve fibers was
presented as a Plenary Lecture at the 2001 meeting of the Peripheral Nerve Society. It is …

Formation of fibrin is critical for limiting blood loss at a site of blood vessel injury (hemostasis),
but may also contribute to vascular thrombosis. Hereditary deficiency of factor XII (FXII), …

Ischemic stroke is the second leading cause of death worldwide. Only one moderately
effective therapy exists, albeit with contraindications that exclude 90% of the patients. This …

Background— Ischemic stroke is a frequent and serious disease with limited treatment options.
Platelets can adhere to hypoxic cerebral endothelial cells by binding of their glycoprotein …

T cells contribute to the pathophysiology of ischemic stroke by yet unknown mechanisms.
Mice with transgenic T-cell receptors (TCRs) and mutations in costimulatory molecules were …

We have recently identified T cells as important mediators of ischemic brain damage, but
the contribution of the different T-cell subsets is unclear. Forkhead box P3 (FoxP3)–positive …

Macrophage-mediated segmental demyelination is the pathological hallmark of
autoimmune demyelinating polyneuropathies, including the demyelinating form of Guillain-Barré …