Background Plasmacytoid dendritic cells have been implicated in the pathogenesis of
systemic sclerosis through mechanisms beyond the previously suggested production of type I …

BACKGROUND. TGF-β has potent profibrotic activity in vitro and has long been implicated
in systemic sclerosis (SSc), as expression of TGF-β–regulated genes is increased in the skin …

Objective To determine the safety of rituximab, to provide preliminary data regarding the
potential efficacy of rituximab, and to investigate the effects of rituximab on autoimmunity and …

Immune activation of fibrosis likely has a crucial role in the pathogenesis of systemic sclerosis
(SSc). The aim of this study was to better understand the innate immune regulation and …

Background Pulmonary arterial hypertension (PAH) is a common complication for individuals
with limited systemic sclerosis (lSSc). The identification and characterization of biomarkers …

OBJECTIVE: To evaluate, in a pilot study, the efficacy of a short term cyclophosphamide (CYC)
pulse regimen on alveolitis in a cohort of patients with systemic sclerosis (SSc). …

Objective To explore the relationship between biomarkers of pulmonary arterial hypertension
(PAH), interferon (IFN)–regulated gene expression, and the alternative activation pathway …

Scleroderma (SSc) is a complex and heterogeneous connective tissue disease mainly
characterized by autoimmunity, vascular damage, and fibrosis that mostly involve the skin and …

The diagnosis of psoriasis, an immune-mediated disease that affects 2% of the population
in Western countries, is largely based on history and clinical examination. The aim of this …

Fibrosis, the hallmark of systemic sclerosis (SSc), is characterized by persistent fibroblast
activation triggered by transforming growth factor-β (TGF-β). As the acetyltransferase p300 has …