Despite being the second least represented granulocyte subpopulation in the circulating
blood, eosinophils are receiving a growing interest from the scientific community, due to their …

Background Circulating androgens could have a relevant pathobiological role in clinical
outcomes in men with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) …

Objective Mepolizumab proved to be an efficacious treatment for eosinophilic granulomatosis
with polyangiitis (EGPA) at a dose of 300 mg every 4 weeks in the randomized, controlled …

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown
cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for …

We conducted a large-scale genetic analysis on giant cell arteritis (GCA), a polygenic
immune-mediated vasculitis. A case-control cohort, comprising 1,651 case subjects with GCA and …

Background Circulating testosterone levels have been found to be reduced in men with
severe acute respiratory syndrome coronavirus 2 infection, COVID‐19, with lower levels being …

Neutrophils recognize particulate substrates of microbial or endogenous origin and react by
sequestering the cargo via phagocytosis or by releasing neutrophil extracellular traps (NETs…

Endothelial cell damage and platelet activation contribute to sustained vasculopathy, which
is a key clinical characteristic of systemic sclerosis (SSc), also known as scleroderma. …

In late February 2020 the Lombardy region (Italy) was dramatically hit by a new infectious
coronavirus disease (COVID-19) caused by the severe acute respiratory syndrome coronavirus…

The link between platelet activation and vascular injury in Systemic Sclerosis (SSc) is poorly
characterized. Here we report that platelet activation results in i) the translocation from the …