Cystic renal diseases are caused by mutations of proteins that share a unique subcellular
localization: the primary cilium of tubular epithelial cells 1 . Mutations of the ciliary protein …

Autosomal-dominant polycystic kidney disease (ADPKD) is a common genetic disorder that
frequently leads to renal failure. Mutations in polycystin-1 (PC1) underlie most cases of …

Nephronophthisis (NPHP), an autosomal recessive cystic kidney disease, leads to chronic
renal failure in children. The genes mutated in NPHP1 and NPHP4 have been identified, and …

Injury and loss of podocytes are leading factors of glomerular disease and renal failure. The
postmitotic podocyte is the primary glomerular target for toxic, immune, metabolic, and …

Endothelial leukocyte adhesion molecule-1 (ELAM-1) is an endothelial cell adhesion
molecule that allows myeloid cells to attach to the walls of blood vessels adjacent to sites of …

Autosomal dominant polycystic kidney disease is the most common inherited kidney disease
and accounts for 7–10% of all patients on renal replacement therapy worldwide. Although …

Wnt signaling cascades activate morphogenetic programs that range from cell migration and
proliferation to cell fate determination and stem cell renewal. These pathways enable cells …

Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity,
represent a major health issue. However, they remain poorly understood. Here we have …

The immunosuppressive drug rapamycin has helped to identify a large signaling network
around the target of rapamycin (TOR) protein that integrates information on nutrient availability …

Mutations of NPHS1 or NPHS2, the genes encoding nephrin and podocin, as well as the
targeted disruption of CD2-associated protein (CD2AP), lead to heavy proteinuria, suggesting …