User profiles for Genny del Zotto

Genny Del Zotto

Istituto G. Gaslini
Verified email at gaslini.org
Cited by 4135

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

S Sivori, P Vacca, G Del Zotto, E Munari… - Cellular & molecular …, 2019 - nature.com
NK cells play important roles in innate defenses against viruses and in the control of tumor
growth and metastasis. The regulation/induction of NK cell function is mediated by an array of …

[HTML][HTML] Killer Ig-like receptors (KIRs): their role in NK cell modulation and developments leading to their clinical exploitation

…, E Munari, A Bertaina, F Moretta, G Del Zotto… - Frontiers in …, 2019 - frontiersin.org
Natural killer (NK) cells contribute to the first line of defense against viruses and to the control
of tumor growth and metastasis spread. The discovery of HLA class I specific inhibitory …

Human NK cell receptors/markers: a tool to analyze NK cell development, subsets and function

E Montaldo, GD Zotto, MD Chiesa, MC Mingari… - Cytometry Part …, 2013 - Wiley Online Library
Natural killer (NK) cells are important components of the innate immunity and play a key role
in host defense by virtue of their ability to release cytokines and to mediate cytolytic activity …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

…, D Davies, S De Biasi, G Del Zotto… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical aspects of …

Guidelines for the use of flow cytometry and cell sorting in immunological studies*

…, D Davies, S De Biasi, G Del Zotto… - European journal of …, 2017 - Wiley Online Library
From a technical point of view a flow cytometer is a light detection device capable of detecting
photons of different wavelengths over a high dynamic range. In order to achieve a high …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

…, S De Biasi, G De Simone, G Del Zotto… - European journal of …, 2021 - Wiley Online Library
The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

[HTML][HTML] PD/1-PD-Ls checkpoint: insight on the potential role of NK cells

S Pesce, M Greppi, F Grossi, G Del Zotto… - Frontiers in …, 2019 - frontiersin.org
The identification of inhibitory NK cell receptors specific for HLA-I molecules (KIRs and
NKG2A) provided the molecular basis for clarifying the mechanism by which NK cells kill …

Human natural killer cells: origin, receptors, function, and clinical applications

L Moretta, E Montaldo, P Vacca, G Del Zotto… - International archives of …, 2014 - karger.com
Natural killer (NK) cells are important effectors playing a relevant role in innate immunity,
primarily in tumor surveillance and in defenses against viruses. Human NK cells recognize HLA …

[PDF][PDF] Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections

…, Q Chen, J Fong, L Marri, G Filaci, G Del Zotto… - Immunity, 2021 - cell.com
A cardinal feature of COVID-19 is lung inflammation and respiratory failure. In a prospective
multi-country cohort of COVID-19 patients, we found that increased Notch4 expression on …

Markers and function of human NK cells in normal and pathological conditions

G Del Zotto, E Marcenaro, P Vacca… - Cytometry Part B …, 2017 - Wiley Online Library
Natural killer (NK) cells, the most important effectors of the innate lymphoid cells (ILCs), play
a fundamental role in tumor immune‐surveillance, defense against viruses and, in general, …