Objective To estimate the global burden of hip and knee osteoarthritis (OA) as part of the
Global Burden of Disease 2010 study and to explore how the burden of hip and knee OA …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

OBJECTIVE: To resolve uncertainty regarding sex differences in osteoarthritis (OA) by
performing a meta-analysis of sex differences in OA prevalence, incidence and severity. …

Background: The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of
IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis. Objective: To evaluate through …

The pioneering work of Tamao and Kumada I and Fleming 2 has introduced synthetic
organic chemists to the concept of using a silicon group as a masked hydroxy group. This …

OBJECTIVE--To investigate the utility of risk factors such as bone mineral density, lifestyle,
and postural stability in the prediction of osteoporotic fractures. DESIGN--Longitudinal, …

OBJECTIVE: The role of inflammation in osteoarthritis (OA) pathogenesis is unclear, and the
associations between inflammatory cytokines and cartilage loss have not been reported. …

Context: IL-1, IL-6, and TNF-α play an important role in the pathogenesis of osteoporosis in
animals; however, evidence that these play a similar role in bone loss in human studies is …

Objective The significance of asymptomatic knee cartilage defects in healthy individuals is
not known. The aim of this study was to examine the association between cartilage defects in …

OBJECTIVE: To generate hypotheses regarding the associations between knee cartilage
defects and knee radiographic osteoarthritis (ROA), cartilage volume, bone size and type II …