[PDF][PDF] Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is …

…, CA Blanchong, KL McBride, GC Higgins… - The American Journal of …, 2007 - cell.com
Interindividual gene copy-number variation (CNV) of complement component C4 and its
associated polymorphisms in gene size (long and short) and protein isotypes (C4A and C4B) …

Anakinra as first‐line disease‐modifying therapy in systemic juvenile idiopathic arthritis: report of forty‐six patients from an international multicenter series

…, K Jones, NT Ilowite, RQ Cron, GC Higgins - Arthritis & …, 2011 - Wiley Online Library
Objective To examine the safety and efficacy of the interleukin‐1 (IL‐1) receptor antagonist
anakinra as first‐line therapy for systemic juvenile idiopathic arthritis (JIA). Methods Patients …

Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis

…, P Chira, BS Gottlieb, GC Higgins… - Arthritis & …, 2012 - Wiley Online Library
Objective To determine whether aggressive treatment initiated early in the course of rheumatoid
factor (RF)–positive or RF‐negative polyarticular juvenile idiopathic arthritis (JIA) can …

Development of consensus treatment plans for juvenile localized scleroderma: a roadmap toward comparative effectiveness studies in juvenile localized scleroderma

…, CE Rabinovich, RM Laxer, GC Higgins… - Arthritis care & …, 2012 - Wiley Online Library
Objective Juvenile localized scleroderma (LS) is a chronic inflammatory skin disorder
associated with substantial morbidity and disability. Although a wide range of therapeutic …

The localized scleroderma skin severity index and physician global assessment of disease activity: a work in progress toward development of localized scleroderma …

…, S Li, KM O'NEIL, E Pope, GC Higgins… - The Journal of …, 2009 - jrheum.org
Objective. To develop and evaluate a Localized Scleroderma (LS) Skin Severity Index (LoSSI)
and global assessments’ clinimetric property and effect on quality of life (QOL). Methods. …

Comparing presenting clinical features in 48 children with microscopic polyangiitis to 183 children who have granulomatosis with polyangiitis (Wegener's): an …

…, ME Elder, A Hersh, GC Higgins… - Arthritis & …, 2016 - Wiley Online Library
Objective To uniquely classify children with microscopic polyangiitis (MPA), to describe their
demographic characteristics, presenting clinical features, and initial treatments in …

Adherence to medications in systemic lupus erythematosus

S Koneru, L Kocharla, GC Higgins, A Ware… - JCR: Journal of …, 2008 - journals.lww.com
Background: Lack of adherence is a ubiquitous problem which can be a hindrance in the
treatment of chronic conditions like systemic lupus erythematosus (SLE). Objectives: A random …

Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima‐media thickness in the Atherosclerosis Prevention in …

…, R Silver, L Wagner‐Weiner, GC Higgins… - Arthritis & …, 2009 - Wiley Online Library
Objective To evaluate risk factors for subclinical atherosclerosis in a population of patients
with pediatric systemic lupus erythematosus (SLE). Methods In a prospective multicenter study…

Health status of patients with juvenile rheumatoid arthritis at 1 and 5 years after diagnosis.

…, GC Higgins, B Adams, LK Myers, C Wallace… - The Journal of …, 2003 - jrheum.org
OBJECTIVE: To describe the health and functional status of children with juvenile rheumatoid
arthritis (JRA) diagnosed in the early 1990s. METHODS: Patients were obtained from the …

Effectively measuring adherence to medications for systemic lupus erythematosus in a clinical setting

…, MH Passo, JL Houk, GC Higgins… - Arthritis Care & …, 2007 - Wiley Online Library
Objective To assess the reliability and concurrent validity of the Medication Adherence Self‐report
Inventory (MASRI) when used in systemic lupus erythematosus (SLE), to investigate …