Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial
MM Berger, F Spertini, A Shenkin, C Wardle… - The American journal of …, 1998 - Elsevier
Infections remain the leading cause of death after major burns. Trace elements are involved
in immunity and burn patients suffer acute trace element depletion after injury. In a previous …
in immunity and burn patients suffer acute trace element depletion after injury. In a previous …
Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease
Objectives Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease;
its management is largely empirical. This is the first clinical study to determine if interleukin (IL)…
its management is largely empirical. This is the first clinical study to determine if interleukin (IL)…
[HTML][HTML] MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
…, GK Scadding, A Sheikh, F Spertini… - Journal of Allergy and …, 2016 - Elsevier
The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several
factors, including age, prominent symptoms, symptom severity, control of AR, patient …
factors, including age, prominent symptoms, symptom severity, control of AR, patient …
[HTML][HTML] Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose …
…, WR Ballou, MP Kieny, V Moorthy, F Spertini… - The Lancet infectious …, 2016 - thelancet.com
Background The ongoing Ebola outbreak led to accelerated efforts to test vaccine candidates.
On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of …
On the basis of a request by WHO, we aimed to assess the safety and immunogenicity of …
[HTML][HTML] A Malaria Vaccine That Elicits in Humans Antibodies Able to Kill Plasmodium falciparum
P Druilhe, F Spertini, D Soesoe, G Corradin… - PLoS …, 2005 - journals.plos.org
Background Plasmodium falciparum merozoite surface protein 3 is a malaria vaccine
candidate that was identified, characterised, and developed based on a unique immuno-clinical …
candidate that was identified, characterised, and developed based on a unique immuno-clinical …
Down‐regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon α–kinoid
BR Lauwerys, E Hachulla, F Spertini… - Arthritis & …, 2013 - Wiley Online Library
Objective We developed interferon‐α–kinoid (IFN‐K), a drug composed of inactivated IFNα
coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα–transgenic mice, IFN…
coupled to a carrier protein, keyhole limpet hemocyanin. In human IFNα–transgenic mice, IFN…
Safety of human immunisation with a live-attenuated Mycobacterium tuberculosis vaccine: a randomised, double-blind, controlled phase I trial
F Spertini, R Audran, R Chakour, O Karoui… - The lancet Respiratory …, 2015 - thelancet.com
Background Tuberculosis remains one of the world's deadliest transmissible diseases despite
widespread use of the BCG vaccine. MTBVAC is a new live tuberculosis vaccine based …
widespread use of the BCG vaccine. MTBVAC is a new live tuberculosis vaccine based …
Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen
…, O Leroy, G Corradin, P Druilhe, F Spertini - Infection and …, 2005 - Am Soc Microbiol
The C-terminal conserved region of Plasmodium falciparum merozoite surface protein 3 (MSP3)
is the trigger antigen of a protective immune response mediated by cytophilic antibodies…
is the trigger antigen of a protective immune response mediated by cytophilic antibodies…
Targeting of secretory IgA to Peyer's patch dendritic and T cells after transport by intestinal M cells
J Rey, N Garin, F Spertini, B Corthésy - The Journal of Immunology, 2004 - journals.aai.org
In addition to being instrumental to the protection of mucosal epithelia, secretory IgA (SIgA)
adheres to and is transported by intestinal Peyer’s patch (PP) M cells. The possible functional …
adheres to and is transported by intestinal Peyer’s patch (PP) M cells. The possible functional …
Adverse reactions to biologic agents and their medical management
Biologic agents have substantially advanced the treatment of immunological disorders,
including chronic inflammatory and autoimmune diseases. However, these drugs are often …
including chronic inflammatory and autoimmune diseases. However, these drugs are often …