User profiles for FRANZ JAKOB

Franz Jakob

Head of Orthopedic Center for Musculoskeletal Research, Chair of Musculoskeletal Center …
Verified email at uni-wuerzburg.de
Cited by 13467

How smart do biomaterials need to be? A translational science and clinical point of view

…, U Gbureck, L Rackwitz, U Nöth, F Jakob… - Advanced drug delivery …, 2013 - Elsevier
Over the last 4 decades innovations in biomaterials and medical technology have had a
sustainable impact on the development of biopolymers, titanium/stainless steel and ceramics …

Effect of ozone on oral cells compared with established antimicrobials

KC Huth, FM Jakob, B Saugel… - European journal of …, 2006 - Wiley Online Library
Ozone has been proposed as an alternative antiseptic agent in dentistry based on reports of
its antimicrobial effects in both gaseous and aqueous forms. This study investigated …

Additive manufacturing of scaffolds with sub-micron filaments via melt electrospinning writing

…, T Jüngst, TD Brown, K Hahn, C Moseke, F Jakob… - …, 2015 - iopscience.iop.org
The aim of this study was to explore the lower resolution limits of an electrohydrodynamic
process combined with direct writing technology of polymer melts. Termed melt electrospinning …

Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite of …

…, JS Burns, B Elsnab, F Jakob… - Biochemical and …, 2005 - Elsevier
Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …

Chondrogenic differentiation of human mesenchymal stem cells in collagen type I hydrogels

…, A Steinert, N Schütze, F Jakob… - … Research Part A: An …, 2007 - Wiley Online Library
The chondrogenic differentiation of bone marrow‐derived human mesenchymal stem cells (MSCs)
in a collagen type I hydrogel, which is in clinical use for matrix‐based autologous …

[HTML][HTML] Selected Novel Flavones Inhibit the DNA Binding or the DNA Religation Step of Eukaryotic Topoisomerase I (∗)

…, K Christiansen, A Andersen, F Jakob… - Journal of Biological …, 1996 - ASBMB
Topoisomerases are involved in many aspects of DNA metabolism such as replication and
transcription reactions. Camptothecins, which stabilize the covalent intermediate of …

Effects of high glucose on mesenchymal stem cell proliferation and differentiation

…, J Seufert, M Kassem, N Schütze, F Jakob… - Biochemical and …, 2007 - Elsevier
High glucose (HG) concentrations impair cellular functions and induce apoptosis. Exposition
of mesenchymal stem cells (MSC) to HG was reported to reduce colony forming activity and …

Novel approaches to target the microenvironment of bone metastasis

LC Hofbauer, A Bozec, M Rauner, F Jakob… - Nature reviews Clinical …, 2021 - nature.com
Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively, …

[HTML][HTML] The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

…, S Zeck, T Schinke, M Amling, R Ebert, F Jakob - 2012 - journals.plos.org
Primary osteoporosis is an age-related disease characterized by an imbalance in bone
homeostasis. While the resorptive aspect of the disease has been studied intensely, less is …

Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro

…, H Stopper, N Schupp, M Kassem, F Jakob - Stem …, 2006 - academic.oup.com
Bone marrow stromal cells (BMSCs) and other cell populations derived from mesenchymal
precursors are developed for cell‐based therapeutic strategies and undergo cellular stress …