Objective Etanercept has been shown to improve the articular and cutaneous manifestations
of psoriatic arthritis (PsA). In this study, we further evaluated the safety, efficacy, and effect …

Background Although opioid analgesics have well-defined efficacy and safety in treatment
of chronic cancer pain, further research is needed to define their role in treatment of chronic …

Introduction AMG 108 is a fully human, immunoglobulin subclass G2 (IgG2) monoclonal
antibody that binds the human interleukin-1 (IL-1) receptor type 1, inhibiting the activity of IL-1a …

OBJECTIVE: Clinical and radiographic responses were evaluated in patients with psoriatic
arthritis (PsA) treated for up to 2 years with etanercept. METHODS: Patients were previously …

Objective. To assess safety and clinical outcomes in patients with inflammatory arthritis after
intraarticular (IA) injection of rAAV2-TNFR:Fc, a recombinant adeno-associated viral vector …

Objective. To evaluate the long-term safety of tacrolimus 3 mg/day in patients with rheumatoid
arthritis (RA). Methods. Patients with active RA who had discontinued all DMARDs for at …

Objective. To evaluate the safety of etanercept in patients with rheumatoid arthritis (RA) and
concomitant comorbidities. Methods. The safety of etanercept (25 mg twice weekly) in RA …

We describe four new patients with a unique syndrome of persistent urticaria, with leukoclastic
angiitis, severe angioedema, occasional life-threatening laryngeal edema, arthritis, …

Introduction Preclinical work has suggested that IL-1 plays a critical role in the pathogenesis
of rheumatoid arthritis (RA). The objective of the present study was to determine the effect of …

This six-month, double-blind, controlled, randomized, parallel study at 13 medical centers
compared the safety and efficacy of nabumetone (1,000 mg taken at bedtime) with that of …