In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for
antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway …

Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor-…

Macrophage activation syndrome (MAS) refers to acute overwhelming inflammation caused
by a'cytokine storm'. Although increasingly recognized as a life-threatening complication of …

Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

… Behrens,6 Fabrizio De Benedetti,7 Lisa Filipovic,8 Alexei A. Grom,8 Jan-Inge Henter,3 …
Strippoli R, Caiello I, de Benedetti F. Reaching the threshold: a multilayer pathogenesis of …

Background Systemic juvenile idiopathic arthritis (JIA) is the most severe subtype of JIA;
treatment options are limited. Interleukin-6 plays a pathogenic role in systemic JIA. Methods We …

Interleukin-6 (IL-6) is overproduced in the joints of patients with rheumatoid arthritis (RA) and,
based on its multiple stimulatory effects on cells of the immune system and on vascular …

… Our findings suggest that IL-6–mediated decrease in IGF-I production represents a major …
The generation of NSE/hIL-6 mice has been described recently (18). Overexpression of hIL-6 in …

Background Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized
by immune dysregulation and hyperinflammation. It typically manifests in infancy and is …

We measured interleukin‐6 (IL‐6) levels in 70 serum samples obtained from 25 patients
with systemic‐onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. …