IL-17 is a newly described, T cell-derived cytokine with ill-defined physiologic properties. As
such, we examined the release of proinflammatory mediators by human macrophages in …

… Negative control experiments with nonspecific IgG showed that the inhibitory effect of the
anti–IL-17 antibody was not due to the nonspecific binding of immunoglobulins to Fc receptor III …

Objective To evaluate the in vitro effects of diacerhein, a new drug for the treatment of
osteoarthritis (OA), and its active metabolite, rhein, on interleukin 1beta (IL-1beta) and tumor …

Objective IL-1β plays a fundamental role in osteoarthritis (OA) pathophysiology and cartilage
destruction. Targeting the activation mechanism of this cytokine appears to be important as …

Objective To study the therapeutic effectiveness of ML‐3000, a new antiinflammatory drug
that has balanced dual inhibitory activity against 5‐lipoxygenase and cyclooxygenase, on the …

Objective To examine the effect of a nonsteroidal antiinflammatory drug, carprofen, on the
structure and metabolism of cartilage and subchondral bone in the experimental osteoarthritic (…

OBJECTIVE: To examine the regulation of tissue inhibitor of metalloproteinase 1 (TIMP-1)
synthesis by interleukin 17 (IL-17) stimulated human monocytes/macrophages in primary …

Introduction and goal Proinflammatory cytokines and prostaglandin E 2 (PGE 2 ) play an
important role in the pathophysiology of osteolysis and implant loosening. The aim of this study …

We revisit the theory of the collective neutral excitation mode in the fractional quantum Hall
effect at Landau level filling fractions ν= 1/3 and ν= 7/3. We include the effect of finite …

Objective To compare the effects of tenidap, a new antirheumatic drug, with a nonsteroidal
anti-inflammatory drug, naproxen, on the synthesis and expression of interleukin-1 beta (IL-1 …