In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia
was identified that affected CD19+/CD27− naive B cells more than CD19+/CD27+ memory B …

This is an executive summary of all consented recommendations of the European Psoriasis
Guidelines–Update 2015. The long version of this guideline is available online as …

Objective Modification of antigens represents a trigger for the generation of autoantibodies.
In the pathogenesis of rheumatoid arthritis (RA), citrullination of proteins has been shown to …

Objective. To delineate the mechanism of the abnormalities in B cell biology found in
patients with primary Sjögren’s syndrome (SS). Methods. The distribution of peripheral B cell …

Despite major progress in the treatment of rheumatoid arthritis (RA), strong unmet medical
need remains, as only a minor proportion of patients reach sustained clinical remission. New …

In patients with rheumatoid arthritis, the induction of rheumatoid factors can be taken as an
indicator of severe disease with a striking involvement of B cell activation. Very recent clinical …

Adult-onset Still’s disease (AoSD) is a rare but clinically well-known, polygenic, systemic
autoinflammatory disease. Owing to its sporadic appearance in all adult age groups with …

Objectives Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease;
its management is largely empirical. This is the first clinical study to determine if interleukin (IL)…

Objective. Apremilast, an oral phosphodiesterase 4 inhibitor, downregulates intracellular
inflammatory mediator synthesis by elevating cyclic adenosine monophosphate levels. The …

Objective. To evaluate the potential of MRI of finger and wrist joints for diagnosing early RA.
MRI was evaluated as a stand-alone tool and in combination with ACR criteria and serum …