Discovering the molecular basis of mitochondrial respiratory chain disease is challenging
given the large number of both mitochondrial and nuclear genes that are involved. We report a …

OBJECTIVE To assess whether pedometers and text messaging increase physical activity
in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS A 12-week …

OBJECTIVE: Chronic relapsing multifocal osteomyelitis (CRMO) results in significant
morbidity, especially in those with vertebral collapse. Symptomatic benefit with intravenous …

Context: Endothelial and smooth muscle dysfunction are critical precursors of atherosclerosis.
These can be detected in children at risk of cardiovascular disease. Objective: The …

Background In about half of all patients with a suspected monogenic disease, genomic
investigations fail to identify the diagnosis. A contributing factor is the difficulty with repetitive …

OBJECTIVE To investigate whether intermittently scanned continuous glucose monitoring (isCGM)
significantly improves glycemic control compared with capillary self-monitored blood …

Endothelial dysfunction occurs early in the development of vascular disease in diabetes.
Total plasma homocyst(e)ine (tHcy) is associated with endothelial dysfunction. We therefore …

BACKGROUND. Endothelial dysfunction, a precursor of vascular disease, begins early in type
1 diabetes mellitus and is associated with folate status. METHODS. A randomized, double-…

McTavish L, Wiltshire E. Effective treatment of hypoglycemia in children with type 1 diabetes:
a randomized controlled clinical trial. Objective: To determine the most effective of four oral …

Background Diabetes is an important cause of morbidity and mortality amongst young people.
Despite improvements in technology, maintenance of good glycaemic control is hard to …