Celiac disease is an immune-mediated enteropathy caused by a permanent sensitivity to
gluten in genetically susceptible individuals. It occurs in children and adolescents with …

Background & Aims: The effects of 6-mercaptopurine (6-MP) are mediated via its intracellular
conversion to 6-thioguanine (6-TG) and 6-methylmercaptopurine (6-MMP) nucleotide …

RESULTS A total of 130 CD patients and 202 controls were studied. Mean age at diagnosis
(±SD) was 14.2 (2.7). There were more male patients (59%). Comparing the highest to the …

BACKGROUND & AIMS:: Approximately 40% of inflammatory bowel disease (1B13) patients
fail to benefit from 6-mercaptopurine (6-MP)/azathioprine (AZA). Recent reports suggest 6-…

Background & Aims: Accurate serological assays are desirable for the diagnosis of inflammatory
bowel disease (IBD) types in the pediatric age group. The aim of this study was to test …

Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator
of innate immunity in humans. Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin …

Background & Aims Increased intestinal permeability has been associated with Crohn’s
disease (CD), but it is not clear whether it is a cause or result of the disease. We performed a …

PURPOSE: To determine if neovascularization associated with Crohn disease, as detected
with Doppler ultrasonography (US), reflects clinical disease activity. MATERIALS AND …

The aim of this review is to examine recent advances in experimental and clinical research
relevant to the pathogenesis of diarrhea-associated hemolytic uremic syndrome with special …

Background Some dietary foods are considered protective (vegetables and fruits), whereas
others (fatty foods) are thought to enhance the risk for Crohn's disease (CD). The evidence, …