We evaluated the effects of the lipophilic nonpeptide corticotropin-releasing hormone (CRH)
type 1 receptor antagonist antalarmin on the behavioral, neuroendocrine, and autonomic …

Corticotropin‐releasing hormone (CRH) influences the immune system indirectly, through
activation of the hypothalamic‐pituitary‐adrenal axis and sympathetic system, and directly, …

Cortic otropin‐releasing hormone (CRH) is a major regulator of the hypothalamic‐pituitary‐adrenal
axis (HPA) and principal coordinator of the stress response. As in stress, …

Objective: Lamotrigine previously was found to attenuate ketamine-induced behavioral
changes and, in 2 placebo-controlled trials, to improve psychosis when added to antipsychotic …

We report here that corticotropin‐releasing factor (CRF) stimulates adenylate cyclase
activity in the rat central nervous system (CNS). In frontoparietal cortex homogenates, the …

OBJECTIVE: To determine whether a corticotropin releasing hormone (CRH) type 1-specific
receptor antagonist, antalarmin, would alter the progression of inflammation in adjuvant …

Rationale Atypical antipsychotic drugs are the drugs of choice for the treatment of schizophrenia.
However, despite advances, no treatments have been established for patients who fail …

CRF is a primary integrator of the organism's coordinated neuroendocrine, autonomic,
behavioral, and immune responses to stress. In the present study the identity of the cell type(s) …

Antalarmin is a pyrrolopyrimidine compound that antagonizes corticotropin-releasing hormone
(CRH) type 1 receptors (CRHR1). In order to assess the effects of antalarmin treatment on …

In sheep, corticotropin-releasing homone (CRH) can stimulate the fetal release of ACTH to
produce a cortisol surge which leads to the onset of parturition. We tested the hypothesis that …