Variation in the safety of induced pluripotent stem cell lines

…, K Tanabe, M Ohnuki, D Ogawa, E Ikeda… - Nature …, 2009 - nature.com
We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated
from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. …

[PDF][PDF] Regulation of the HIF-1α level is essential for hematopoietic stem cells

K Takubo, N Goda, W Yamada, H Iriuchishima, E Ikeda… - Cell stem cell, 2010 - cell.com
Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as
the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic …

[PDF][PDF] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells

…, A Nakamura-Ishizu, H Kobayashi, E Ikeda… - Cell stem cell, 2013 - cell.com
Defining the metabolic programs that underlie stem cell maintenance will be essential for
developing strategies to manipulate stem cell capacity. Mammalian hematopoietic stem cells (…

[HTML][HTML] Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells (∗)

E Ikeda, MG Achen, G Breier, W Risau - Journal of Biological Chemistry, 1995 - ASBMB
Vascular endothelial growth factor (VEGF) is an endothelial specific angiogenic mitogen
secreted from various cell types including tumor cells. Increasing evidence suggests that VEGF …

Grafted human-induced pluripotent stem-cell–derived neurospheres promote motor functional recovery after spinal cord injury in mice

…, M Koike, Y Uchiyama, E Ikeda… - Proceedings of the …, 2011 - National Acad Sciences
Once their safety is confirmed, human-induced pluripotent stem cells (hiPSCs), which do not
entail ethical concerns, may become a preferred cell source for regenerative medicine. Here…

Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury

…, Y Matsuzaki, M Yuzaki, E Ikeda… - Proceedings of the …, 2010 - National Acad Sciences
Various types of induced pluripotent stem (iPS) cells have been established by different
methods, and each type exhibits different biological properties. Before iPS cell-based clinical …

[HTML][HTML] Matrix metalloproteinases cleave connective tissue growth factor and reactivate angiogenic activity of vascular endothelial growth factor 165

G Hashimoto, I Inoki, Y Fujii, T Aoki, E Ikeda… - Journal of Biological …, 2002 - ASBMB
Vascular endothelial growth factor (VEGF), a potent angiogenic mitogen, plays a crucial role
in angiogenesis under various pathophysiological conditions. We have recently …

Steps toward safe cell therapy using induced pluripotent stem cells

…, K Yoshida, Y Okada, O Tsuji, S Nori, E Ikeda… - Circulation …, 2013 - Am Heart Assoc
The enthusiasm for producing patient-specific human embryonic stem cells using somatic
nuclear transfer has somewhat abated in recent years because of ethical, technical, and …

Double-phase helical CT of small renal parenchymal neoplasms: correlation with pathologic findings and tumor angiogenesis

M Jinzaki, A Tanimoto, M Mukai, E Ikeda… - Journal of computer …, 2000 - journals.lww.com
Purpose To correlate the enhancement pattern of double-phase helical computed
tomography (CT) of small renal parenchymal neoplasms with pathologic findings and tumor …

Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF‐induced angiogenesis

…, H Nakamura, K Makino, E Ikeda… - The FASEB …, 2002 - Wiley Online Library
Vascular endothelial growth factor (VEGF) is a strong angiogenic mitogen and plays
important roles in angiogenesis under various pathophysiological conditions. The in vivo …