Systemic sclerosis (SSc; also called scleroderma) is a complex multisystem disorder with
heterogeneous clinical features. The disease is broadly divided by clinical phenotypes, which …

The UK Scleroderma Study Group developed guidelines on the diagnosis and management
of scleroderma renal crisis (SRC) based on best available evidence and clinical experience…

Background A translational study in renal transplantation suggested YKL-40, a chitinase 3-like-1
gene product, plays an important role in acute kidney injury (AKI) and repair, but data …

Objective The absence of a gold standard for scleroderma renal crisis (SRC) has hindered
our understanding of this problem. The objective of this scoping review was to identify the …

Objective Scleroderma renal crisis (SRC) is a life-threatening complication of systemic sclerosis
(SSc) strongly associated with anti-RNA polymerase III antibody (ARA) autoantibodies. …

Background We report results from a phase II randomised placebo-controlled trial assessing
zibotentan, a highly selective endothelin receptor antagonist (ERA), in chronic kidney …

Objective. Renal involvement is common in systemic sclerosis (scleroderma; SSc) and
includes chronic kidney disease (CKD). We have performed analysis of urinary proteins to gain …

Opinion statement The major renal manifestation of systemic sclerosis is scleroderma renal
crisis (SRC). This condition is characterized by accelerated phase hypertension and acute …

Mrs M is a 53-year-old Caucasian nurse who was previously fit and well. Her only prior
medical history is of essential hypertension, for which she has taken ramipril 5 mg daily for 2 …

Importance Ultra-widefield (UWF) imaging improves the ability to identify peripheral diabetic
retinopathy (DR) lesions compared with standard imaging. Whether detection of …