Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation-related cancer and represents a paradigm …

Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key
regulator of cell survival and aberrant NF-κB signaling has been involved in the …

Several inflammatory diseases have been associated with increased bone resorption and
fracture rates and different studies supported the relation between inflammatory cytokines and …

The multiplicity of Notch receptors raises the question of the contribution of specific isoforms
to T-cell development. Notch3 is expressed in CD4±8±thymocytes and is down-regulated …

E2F1, a member of the E2F family of transcription factors, in addition to its established
proliferative effect 1 , has also been implicated in the induction of apoptosis through p53-…

Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma,
which arises from aberrant development of cerebellar granule progenitors. Allelic loss of …

Breast cancer cells are usually sensitive to several chemotherapeutic regimens, but they
can develop chemoresistance after prolonged exposure to cytotoxic drugs, acquiring a more …

The retinoblastoma protein (pRB) tumor suppressor blocks cell proliferation by repressing
the E2F transcription factors. This inhibition is relieved through mitogen-induced …

The full activation of T cells necessitates the concomitant activation of two signals, the
engagement of T-cell receptor by peptide/major histocompatibility complex II and an additional …

Cancer is a multistep process characterized by various and different genetic lesions which
cause the transformation of normal cells into tumor cells. To preserve the genomic integrity, …