Background We evaluated the safety and efficacy of etanercept, a soluble tumor necrosis
factor receptor (p75):Fc fusion protein, in children with polyarticular juvenile rheumatoid …

Objective To investigate potential differences between childhood‐onset and adult‐onset
systemic lupus erythematosus (SLE). Methods An inception cohort with childhood‐onset SLE (n …

Objective To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid
arthritis (JRA). Methods This was an international, multicenter, randomized, placebo‐…

Purpose Genetic testing is an integral diagnostic component of pediatric medicine. Standard
of care is often a time-consuming stepwise approach involving chromosomal microarray …

OBJECTIVES: To determine the frequency and characteristics of clinical signs, symptoms,
laboratory findings, and medication use in children with pediatric systemic lupus …

Objectives : We reviewed our institution’s experience with isolated (congenital) third-degree
atrioventricular block (CAVB) to identify pre- and post-natal predictors of mortality and the …

Background— Untreated isolated fetal complete atrioventricular block (CAVB) has a significant
mortality rate. A standardized treatment approach, including maternal dexamethasone at …

Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease with a
highly variable clinical course. Pediatric-onset SLE (pSLE) represents 10–20% of all SLE …

To assess factors influencing the success of whole-genome sequencing for mainstream
clinical diagnosis, we sequenced 217 individuals from 156 independent cases or families …

… -onset SLE patients who completed treatment with cyclophosphamide but were not
included in the study because of the chosen time frame reported persistent amenorrhea (Silverman …