Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis …

AI Catrina, C Trollmo, E af Klint… - … : Official Journal of …, 2005 - Wiley Online Library
Objective Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF) antagonists
is highly effective, but their mechanisms of action are not completely clear. Since anti‐TNF …

Citrullination is an inflammation-dependent process

D Makrygiannakis, E af Klint, IE Lundberg… - Annals of the …, 2006 - ard.bmj.com
Objectives: To study the presence of citrullinated proteins in inflammatory conditions and in
clinically non-affected tissues of controls. Methods: Synovial biopsy specimens from 19 …

[HTML][HTML] Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids

…, M Korotkova, AI Catrina, L Backman, E Af Klint… - Arthritis research & …, 2009 - Springer
Introduction It was previously shown that lipoxygenase (LO) pathways are important in the
rheumatoid arthritis (RA) inflammatory process and that synovial fluid from RA patients …

Anti–tumor necrosis factor therapy increases synovial osteoprotegerin expression in rheumatoid arthritis

AI Catrina, E Klint, S Ernestam… - … : Official Journal of …, 2006 - Wiley Online Library
Objective Treatment of rheumatoid arthritis (RA) with tumor necrosis factor (TNF)–blocking
agents, including etanercept and infliximab, has resulted in reductions in the radiographic …

Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels

E Klint, C Grundtman, M Engström… - Arthritis & …, 2005 - Wiley Online Library
Objective To investigate whether intraarticular (IA) glucocorticoid (GC) therapy diminishes
synovial cell infiltration, vascularity, expression of proinflammatory cytokines, and adhesion …

[HTML][HTML] Skewed distribution of proinflammatory CD4+CD28nullT cells in rheumatoid arthritis

…, B Nordmark, A Rahbar, E af Klint… - Arthritis research & …, 2007 - Springer
Expanded populations of CD4 + T cells lacking the co-stimulatory molecule CD28 (CD4 +
CD28 null T cells) have been reported in several inflammatory disorders. In rheumatoid arthritis…

Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis

H Wittkowski, D Foell, E af Klint, L De Rycke… - Annals of the …, 2007 - ard.bmj.com
Objective: The pro-inflammatory calcium-binding protein S100A12 has been recently ascribed
to the novel group of damage associated molecular pattern (DAMP) molecules. Serum …

[HTML][HTML] Effect of infliximab on mRNA expression profiles in synovial tissue of rheumatoid arthritis patients

J Lindberg, E af Klint, AI Catrina, P Nilsson… - Arthritis research & …, 2006 - Springer
We examined the gene expression profiles in arthroscopic biopsies retrieved from 10
rheumatoid arthritis patients before and after anti-TNF treatment with infliximab to investigate …

[HTML][HTML] Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

U Hardt, K Carlberg, E af Klint, P Sahlström… - Scientific reports, 2022 - nature.com
B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear
to what extent differentiated B cells are present in joint tissue already at the onset of disease…

Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway

…, M Westman, KR Gheorghe, E af Klint… - Arthritis & …, 2005 - Wiley Online Library
Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) is up‐regulated in experimental
arthritis and markedly expressed in synovial tissue biopsy samples from patients with …