Obesity and a central body fat distribution, hypertension, insulin resistance, glucose
intolerance, dyslipidemia, and proinflammatory and prothrombotic factors are all part of the …

Obesity is an important risk factor for insulin resistance and hypertension and plays a central
role in the metabolic syndrome. Insight into the pathophysiology of this syndrome may lead …

Please cite this paper as: de Boer, Meijer, Wijnstok, Jonk, Houben, Stehouwer, Smulders,
Eringa and Serné (2012). Microvascular Dysfunction: A Potential Mechanism in the …

Background— Obesity is associated with an increased risk of developing microangiopathy,
hypertension, and insulin resistance. We hypothesized that obesity is a primary cause of …

Capillary rarefaction occurs in many tissues in patients with essential hypertension and may
contribute to an increased vascular resistance and impaired muscle metabolism. …

Background Patients with type 1 diabetes who have impaired awareness of hypoglycaemia
have a three to six times increased risk of severe hypoglycaemia. We aimed to assess …

Current strategies combining anti-angiogenic drugs with chemotherapy provide clinical
benefit in cancer patients. It is assumed that anti-angiogenic drugs, such as bevacizumab, …

Background—A strong but presently unexplained inverse association between blood pressure
and insulin sensitivity has been reported. Microvascular vasodilator capacity may be a …

To test the hypothesis that free fatty acids (FFAs) modulate microvascular function and that
this contributes to obesity-associated insulin resistance, hypertension, and microangiopathy, …

An effect on microvascular function has been proposed as a possible mechanism explaining
the association of acute smoking with increased blood pressure and decreased insulin …