More than three decades after the discovery of HLA-B27 as a major genetic clue to the origins
of ankylosing spondylitis, much has been learned about pathogenesis. However, the role …

Objective Ankylosing spondylitis (AS) is diagnosed late, because radiographs of the sacroiliac
joints often do not show definite sacroiliitis at the time of disease onset. The aim of this …

Objective To assess prospectively the rates and to explore predictors of spinal radiographic
progression over 2 years in a cohort of patients with early axial spondylarthritis (SpA). …

Objective To assess the progression of radiographic sacroiliitis in a cohort of patients with
early axial spondyloarthritis over a period of 2 years and to explore predictors of progression. …

… be explained by the inhibition of prostaglandins (especially prostaglandin E 2 ) synthesis
mediated by COX-2.29 Prostaglandin E 2 is able to stimulate new bone formation by increasing …

Objective Cytokines play a critical role in the pathogenesis of arthritis. The aim of this study
was to compare the amounts of IL-1 alpha, IL-1 beta, IL-4, IL-6, IL-8, IL-10, IL-12, TNF-alpha, …

Tumor necrosis factor-α is considered to be one of the important mediators in the
pathogenesis of psoriasis. A strong association of juvenile onset psoriasis with the major …

… We find that human γδ T cells bind to E-selectin and P-selectin. P-selectin binding by γδ
T cells is enhanced compared with αβ T cells [32]. Bovine γδ T cells also bind to …

Background/Aims: Autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing
cholangitis are chronic liver diseases with probable autoimmune background. Overlapping …

Today, women with inflammatory rheumatic diseases are normally fertile and can be encouraged
to become pregnant, when there is a stable and quiescent phase of the disease. This …