Structure and biology of cartilage and bone matrix noncollagenous macromolecules

D Heinegård, åke Oldberg - The FASEB Journal, 1989 - Wiley Online Library
Over recent years a number of cartilage and bone matrix molecules have been identified and
characterized. These include major constituents such as collagens and proteoglycans as …

The role of the cartilage matrix in osteoarthritis

D Heinegård, T Saxne - Nature Reviews Rheumatology, 2011 - nature.com
Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and what
factors trigger the disease process remain unclear, although the mechanical environment …

Fell‐Muir Lecture: Proteoglycans and more–from molecules to biology

D Heinegård - International journal of experimental pathology, 2009 - Wiley Online Library
In this article the organization and functional details of the extracellular matrix, with particular
focus on cartilage, are described. All tissues contain a set of molecules that are arranged to …

[HTML][HTML] Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.

…, M Wendel, A Oldberg, D Heinegård - Journal of biological …, 1992 - Elsevier
An Mr = 524,000 oligomeric protein was isolated from bovine cartilage and designated
COMP (Cartilage Oligomeric Matrix Protein). The protein is composed of disulfide-bonded …

[HTML][HTML] Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon

…, FP Reinholt, R Fässler, D Heinegård… - Journal of Biological …, 1999 - ASBMB
Fibromodulin is a member of a family of connective tissue glycoproteins/proteoglycans
containing leucine-rich repeat motifs. Several members of this gene family bind to fibrillar …

IL-1αβ blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-α blockade only ameliorates joint inflammation

…, T Saxne, FAJ van de Loo, D Heinegård… - The Journal of …, 1999 - journals.aai.org
Anti-TNF-α treatment of rheumatoid arthritis patients markedly suppresses inflammatory
disease activity, but so far no tissue-protective effects have been reported. In contrast, blockade …

[HTML][HTML] Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen

…, H Olsson, M Mörgelin, D Heinegård - Journal of Biological …, 1998 - ASBMB
Cartilage and tendon extracellular matrices are composed of collagens, proteoglycans, and
a number of noncollagenous proteins. Cartilage oligomeric matrix protein (COMP) is a …

[HTML][HTML] COMP acts as a catalyst in collagen fibrillogenesis

…, A Kassner, M Mörgelin, D Heinegård - Journal of biological …, 2007 - ASBMB
We have previously reported that COMP (cartilage oligomeric matrix protein) is prominent in
cartilage but is also present in tendon and binds to collagens I and II with high affinity. Here …

[HTML][HTML] Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan

…, M Paulsson, JF Bateman, D Heinegård… - Journal of Biological …, 2003 - ASBMB
Native supramolecular assemblies containing collagen VI microfibrils and associated
extracellular matrix proteins were isolated from Swarm rat chondrosarcoma tissue. Their …

The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein–protein interactions independent of …

…, M Shimonaka, D Heinegård… - Proceedings of the …, 1997 - National Acad Sciences
The lecticans are a family of chondroitin sulfate proteoglycans including aggrecan, versican,
neurocan, and brevican. The C-terminal globular domains of lecticans are structurally …