Objectives Interferon-γ (IFNγ) is the pivotal mediator in murine models of primary haemophagocytic
lymphohistiocytosis (pHLH). Given the similarities between primary and secondary …

Objectives Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal
osteomyelitis (CRMO) is an autoinflammatory disorder characterized by sterile bone osteolytic …

Objective To evaluate the demographic, disease activity, disability, and health‐related quality
of life (HRQOL) differences between children with juvenile idiopathic arthritis (JIA) and …

Objective To evaluate the expression of type I interferon ( IFN α/β)– and type II IFN ( IFN γ)–inducible
genes in muscle biopsy specimens from patients with juvenile dermatomyositis ( …

Objective. Anti-TNF-α agents have significantly changed the management of juvenile idiopathic
arthritis (JIA). We evaluated the safety and efficacy of adalimumab (ADA) and infliximab (…

Background Pathogenic missense variants in cell division control protein 42 (CDC42)
differentially affect protein function, causing a clinically wide phenotypic spectrum variably …

Objective To evaluate the impact of early treatment and IL1RN genetic variants on the response
to anakinra in systemic juvenile idiopathic arthritis (JIA). Methods Response to anakinra …

Background Chronic nonbacterial osteomyelitis (CNO) is a rare autoinflammatory bone
disorder. Little information exists on the use of imaging techniques in CNO. Materials and …

Objective. To assess anakinra as a therapy for systemic juvenile idiopathic arthritis (sJIA) in
a single-center series. Methods. We reviewed 25 patients with sJIA treated with anakinra for …

Objective To assess the composition of gut microbiota in Italian and Dutch patients with
juvenile idiopathic arthritis ( JIA ) at baseline, with inactive disease, and with persistent activity …