MICE with targeted disruptions 1 in Hoxgenes have been generated to evaluate the role of
the Hox complex in determining the mammalian body plan. This complex of 38 genes …

Anaplastic Lymphoma Kinase (ALK) was originally identified as a member of the insulin
receptor subfamily of receptor tyrosine kinases that acquires transforming capability when …

The development of characteristic visceral asymmetries along the left–right (LR) axis in an
initially bilaterally symmetrical embryo is an essential feature of vertebrate patterning. The …

Asthma is on the rise despite intense, ongoing research underscoring the need for new
scientific inquiry. In an effort to provide unbiased insight into disease pathogenesis, we took an …

The leukocyte integrin α M β 2/Mac-1 appears to support the inflammatory response through
multiple ligands, but local engagement of fibrin (ogen) may be particularly important for …

Hoxa 11 is a murine Abdominal-B-type homeobox gene. The structure of this gene is presented,
including genomic and cDNA sequence. The cDNA includes the complete open reading …

Tissue factor (TF) is the cellular receptor for coagulation factor VI/VIIa and is the membrane-bound
glycoprotein that is generally viewed as the primary physiological initiator of blood …

Hereditary hemochromatosis is an autosomal recessive disorder, the gene for which occurs
in approximately 10% of Americans, most of whom are unaffected heterozygotes. …

Objective Renal involvement in systemic lupus erythematosus (SLE) is associated with poor
prognosis. Currently available renal biomarkers are relatively insensitive and nonspecific for …

● Objective.—To review the state of the art as reflected in the medical literature and the
consensus opinion of recognized experts in the field regarding the laboratory monitoring of …