User profiles for David Saadoun

SAADOUN

Professeur de médecine interne
Verified email at aphp.fr
Cited by 26067

[HTML][HTML] Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis

D Saadoun, M Rosenzwajg, F Joly, A Six… - … England Journal of …, 2011 - Mass Medical Soc
Background Patients with vasculitis induced by the hepatitis C virus (HCV) have reduced levels
of regulatory T cells (Tregs). Resolution of HCV infection correlates with cure of vasculitis …

Rituximab plus Peg-interferon-α/ribavirin compared with Peg-interferon-α/ribavirin in hepatitis C–related mixed cryoglobulinemia

D Saadoun, M Resche Rigon, D Sene… - Blood, The Journal …, 2010 - ashpublications.org
Abstract Treatment of hepatitis C (HCV)–mixed cryoglobulinemia (MC) may target either the
viral trigger (HCV) or the downstream B-cell clonal expansion. Prospective cohort study of …

Antiviral therapy for hepatitis C virus–associated mixed cryoglobulinemia vasculitis: a long‐term followup study

D Saadoun, M Resche‐Rigon… - … : Official Journal of …, 2006 - Wiley Online Library
Objective To evaluate the long‐term efficacy of anti–hepatitis C virus (HCV) therapy in
patients with HCV‐associated mixed cryoglobulinemia (HCV‐MC) vasculitis and to assess the …

Mortality in Behçet's disease

D Saadoun, B Wechsler, K Desseaux… - Arthritis & …, 2010 - Wiley Online Library
Objective To report the long‐term mortality in patients with Behçet's disease (BD). Methods A
cohort of 817 patients fulfilling the international criteria for BD from a single center in France …

New insights into the pathogenesis of Behcet's disease

…, B Wechsler, G Geri, P Cacoub, D Saadoun - Autoimmunity …, 2012 - Elsevier
Behçet's disease (BD) is a recurrent systemic inflammatory disorder of unknown origin
characterized by oral and genital mucous ulcer, uveitis, and skin lesions. Involvement of large …

Extrahepatic manifestations of chronic hepatitis C virus infection

…, L Savey, AC Desbois, D Saadoun - Therapeutic …, 2016 - journals.sagepub.com
During hepatitis C virus (HCV) chronic infection, extrahepatic manifestations are frequent
and polymorphous. This article reports on a large cohort of patients with HCV-related …

[HTML][HTML] Behçet's disease physiopathology: a contemporary review

MJ Zeidan, D Saadoun, M Garrido, D Klatzmann… - Autoimmunity …, 2016 - Springer
Behçet’s disease, also known as the Silk Road Disease, is a rare systemic vasculitis disorder
of unknown etiology. Recurrent attacks of acute inflammation characterize Behçet’s disease…

2018 update of the EULAR recommendations for the management of Behçet's syndrome

…, R Moots, Y Ozguler, J Richter, D Saadoun… - Annals of the …, 2018 - ard.bmj.com
Several new treatment modalities with different mechanisms of action have been studied in
patients with Behçet’s syndrome (BS). The aim of the current effort was to update the …

Complement receptor 2/CD21 human naive B cells contain mostly autoreactive unresponsive clones

…, L Menard, G Meyers, D Saadoun… - Blood, The Journal …, 2010 - ashpublications.org
Complement receptor 2–negative (CR2/CD21 − ) B cells have been found enriched in patients
with autoimmune diseases and in common variable immunodeficiency (CVID) patients …

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

…, A Mekinian, E Regnier, D Saadoun… - Annals of the …, 2019 - ard.bmj.com
Objective Regulatory T cells (Tregs) prevent autoimmunity and control inflammation.
Consequently, any autoimmune or inflammatory disease reveals a Treg insufficiency. As low-dose …