User profiles for David R. Jayne

David Jayne

Professor of Clinical Autoimmunity, University of Cambridge
Verified email at cam.ac.uk
Cited by 74192

ANCA-associated vasculitis

…, N Basu, E Brouwer, J Gordon, DR Jayne… - Nature reviews Disease …, 2020 - nature.com
The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are a group
of disorders involving severe, systemic, small-vessel vasculitis and are characterized by …

Histopathologic classification of ANCA-associated glomerulonephritis

…, F Ferrario, EC Hagen, DR Jayne… - Journal of the …, 2010 - journals.lww.com
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is the most common
cause of rapidly progressive glomerulonephritis worldwide, and the renal biopsy is the gold …

Lupus nephritis management guidelines compared

…, L Lightstone, V Tesar, DR Jayne - Nephrology Dialysis …, 2016 - academic.oup.com
In the past years, many (randomized) trials have been performed comparing the treatment
strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines …

Effect of rituximab on malignancy risk in patients with ANCA-associated vasculitis

…, R Wolterbeek, JA Bruijn, DR Jayne… - Annals of the …, 2017 - ard.bmj.com
Objectives Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV)
treated with cyclophosphamide have an increased malignancy risk compared with the …

Tubular lesions predict renal outcome in antineutrophil cytoplasmic antibody–associated glomerulonephritis after rituximab therapy

…, R Waldherr, JA Bruijn, DR Jayne… - Journal of the …, 2012 - journals.lww.com
Histopathological features in renal biopsies of patients with antineutrophil cytoplasmic
antibody–associated vasculitis have predictive value for renal outcome in patients who receive …

Increased apoptosis of bone marrow CD34+ cells and impaired function of bone marrow stromal cells in patients with systemic lupus erythematosus

…, DT Boumpas, FM Gibson, DR Jayne… - British journal of …, 2001 - Wiley Online Library
The changes in bone marrow (BM) stem cell reserve and function and stromal cell function
in patients with active systemic lupus erythematosus (SLE) were investigated. The study was …

Anti–glomerular basement membrane disease after alemtuzumab

…, EF Wallin, DR Jayne - New England Journal of …, 2008 - Mass Medical Soc
To the Editor: Alemtuzumab (Campath-1H) is a humanized anti-CD52 monoclonal antibody,
the administration of which causes profound B- and T-lymphocyte depletion. It is licensed for …

[HTML][HTML] Evaluation of the safety and efficacy of avacopan, a C5a receptor inhibitor, in patients with antineutrophil cytoplasmic antibody–associated vasculitis treated …

PA Merkel, DR Jayne, C Wang… - JMIR research …, 2020 - researchprotocols.org
Background: Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a serious,
often life-threatening disease. In new-onset disease or a relapse, the standard treatment is …

Somatostatin receptor PET/MR imaging of inflammation in patients with large vessel vasculitis and atherosclerosis

…, C Pericleous, S Dubash, N Jordan, DR Jayne… - Journal of the American …, 2023 - jacc.org
Background Assessing inflammatory disease activity in large vessel vasculitis (LVV) can be
challenging by conventional measures. Objectives We aimed to investigate somatostatin …

Comparison of the phenotype and outcome of granulomatosis with polyangiitis between UK and Japanese cohorts

…, S Homma, N Rasmussen, DR Jayne - The Journal of …, 2017 - jrheum.org
Objective. There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)–associated
vasculitis subgroups between different geographic regions, and we …