Background Transcatheter aortic-valve replacement (TAVR) is an alternative to surgery in
patients with severe aortic stenosis who are at increased risk for death from surgery; less is …

Background Although transcatheter aortic-valve replacement (TAVR) is an accepted alternative
to surgery in patients with severe aortic stenosis who are at high surgical risk, less is …

1 Purpose These reporting guidelines are intended to facilitate analysis and reporting of clinical
results of various therapeutic approaches to diseased heart valves such that meaningful …

Background We compared transcatheter aortic-valve replacement (TAVR), using a self-expanding
transcatheter aortic-valve bioprosthesis, with surgical aortic-valve replacement in …

Over the last 10–15 years, our understanding of the composition and functions of the human
gut microbiota has increased exponentially. To a large extent, this has been due to new ‘…

Background Atrial fibrillation (AF) after coronary artery bypass surgery (CABG) is the most
common sustained arrhythmia. Its pathophysiology is unclear, and its prevention and …

Background Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory
properties. This study evaluates the efficacy and safety of baricitinib in combination …

… for research and testing purposes and is on the speakers' bureau of GE Healthcare; David
H. Adams, MD, serves as a consultant and inventor with royalties for Edwards Lifesciences; …

Background Severe tricuspid regurgitation is a debilitating condition that is associated with
substantial morbidity and often with poor quality of life. Decreasing tricuspid regurgitation …

Normal intestinal mucosa contains abundant immunoglobulin A (IgA)–secreting cells, which
are generated from B cells in gut-associated lymphoid tissues (GALT). We show that …