The influenza virus polymerase, a heterotrimer composed of three subunits, PA, PB1 and
PB2, is responsible for replication and transcription of the eight separate segments of the viral …

Influenza virus mRNAs are synthesized by the trimeric viral polymerase using short capped
primers obtained by a 'cap-snatching' mechanism. The polymerase PB2 subunit binds the 5…

A key step in many chromatin-related processes is the recognition of histone post-translational
modifications by effector modules such as bromodomains and chromo-like domains of the …

The trimeric influenza virus polymerase, comprising subunits PA, PB1 and PB2, is responsible
for transcription and replication of the segmented viral RNA genome. Using a novel library…

The heterotrimeric RNA-dependent RNA polymerase of influenza viruses catalyzes RNA
replication and transcription activities in infected cell nuclei. The nucleotide polymerization …

Understanding how avian influenza viruses adapt to human hosts is critical for the monitoring
and prevention of future pandemics. Host specificity is determined by multiple sites in …

Influenza virus polymerase transcribes or replicates the segmented RNA genome (vRNA)
into respectively viral mRNA or full-length copies and initiates RNA synthesis by binding the …

During viral replication, herpesviruses package their DNA into the procapsid by means of
the terminase protein complex. In human cytomegalovirus (herpesvirus 5), the terminase is …

The influenza polymerase transcribes and replicates the viral RNA genome within the context
of a ribonucleoprotein complex that has been hitherto remarkably intractable to structural …

Influenza A virus polymerase subunit PB2 is a major virulence determinant implicated in
pathogenicity and host adaptation. During cross-species virus transfer from avian to mammalian …