Objective CCR2 is a chemokine receptor expressed by monocytes, macrophages, and a
subset of T cells. Its ligand, CCL2 (monocyte chemotactic protein 1), is abundantly present in …

Objective To study the specific effects of rituximab treatment on the synovium in patients with
rheumatoid arthritis (RA) early after initiation of treatment. Methods Seventeen RA patients …

Introduction Accumulating evidence suggests an important role for interleukin 17 (IL-17) in
the pathogenesis of several inflammatory diseases, including rheumatoid arthritis (RA) and …

Background Chemerin is a specific chemoattractant for macrophages and dendritic cells (DC).
In addition, it can rapidly stimulate macrophage adhesion to extracellular matrix proteins …

Background: Previous work identified synovial sublining macrophage numbers as a
potential biomarker for clinical efficacy in rheumatoid arthritis. Objective: To investigate the …

… Danielle M Gerlag1, … of disease, leading to the discovery that circulating autoantibodies,
specifically immunoglobulin M-RF and ACPA, and increased acute phase reactants precede the …

Objective: To investigate the synovial tissue in patients with rheumatoid arthritis (RA) treated
with rituximab and to identify possible predictors of clinical response. Methods: A total of 24 …

Objective Chemokines such as CCL2/monocyte chemotactic protein 1 (MCP‐1) play a key
role in leukocyte migration and are potential targets in the treatment of chronic inflammatory …

Objective Inhibitor of nuclear factor κB kinase β (IκB kinase β, or IKKβ) has emerged as a key
regulator of the transcription factor nuclear factor κB (NF‐κB). Since IKKβ could have both …

Objectives Rheumatoid arthritis (RA) is a prototypic chronic inflammatory disease with a
debilitating course if untreated. A genetic predisposition for RA is known, and its occurrence is …